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Purpose <p>Valvular heart disease (VHD) and Diabetes Mellitus (DM) often coexist, amplifying cardiovascular risk and contributing to increased mortality. Despite their growing burden, national mortality trends among individuals with both conditions remain underexplored.</p> Methods <p>Using CDC-WONDER data (1999–2024), we analyzed deaths among U.S. adults aged ≥ 25 years with both VHD (ICD-10: I05–I08, I34–I37) and DM (E10–E14) as listed causes. Age-adjusted mortality rates (AAMRs) were calculated and stratified by demographics and geography. Joinpoint regression identified changes in annual percent changes (APCs) and average annual percent changes (AAPCs) with 95% confidence intervals (CIs).</p> Results <p>From 1999 to 2024, 133,289 deaths were attributed to VHD and DM. The overall AAMR increased from 1.94 to 2.93 per 100,000. Males consistently had higher mortality than females (3.66 vs. 2.38 in 2024). By race/ethnicity, the highest 2024 AAMR was among non-Hispanic (NH) White populations (3.08), followed by Hispanic (2.49) and NH Black individuals (2.46). Rural areas had higher mortality (3.23) than urban areas (2.56). The West (3.57) and Midwest (3.25) showed the greatest increases. While most deaths occurred in older adults (≥ 65 years), the most rapid increase was in younger adults (AAPC: 2.15%, <i>p</i> &lt; 0.05).</p> Conclusion <p>Mortality from VHD and DM has risen significantly over 25 years, with persistent disparities. Men, NH Whites, and rural residents bear disproportionate burdens. Early diagnosis, timely intervention, and equitable care access are crucial to address these inequities.</p>

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Trends and disparities in valvular heart disease–related mortality among adults with diabetes mellitus in the United States: 1999–2024

  • 期刊论文

  • 发表日期：

    2026年6月16日

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  • Shaikh Muhammad Daniyal,
  • Amna Noor,
  • Mahwish Sarwar,
  • Syeda Laiba Fahim,
  • Ayesha Iftikhar,
  • Habiba Tauqir Gondal,
  • Fizza Batool,
  • Shireen Asifa,
  • Naveen Murad Khatoon,
  • Isbah Gul,
  • Zunaira Aftab,
  • Minahil Riaz,
  • Hareem Ajaz,
  • Muhammad Asfandyar Nadir,
  • Ibrahim Nagmeldin Hassan

摘要

Purpose

Valvular heart disease (VHD) and Diabetes Mellitus (DM) often coexist, amplifying cardiovascular risk and contributing to increased mortality. Despite their growing burden, national mortality trends among individuals with both conditions remain underexplored.

Methods

Using CDC-WONDER data (1999–2024), we analyzed deaths among U.S. adults aged ≥ 25 years with both VHD (ICD-10: I05–I08, I34–I37) and DM (E10–E14) as listed causes. Age-adjusted mortality rates (AAMRs) were calculated and stratified by demographics and geography. Joinpoint regression identified changes in annual percent changes (APCs) and average annual percent changes (AAPCs) with 95% confidence intervals (CIs).

Results

From 1999 to 2024, 133,289 deaths were attributed to VHD and DM. The overall AAMR increased from 1.94 to 2.93 per 100,000. Males consistently had higher mortality than females (3.66 vs. 2.38 in 2024). By race/ethnicity, the highest 2024 AAMR was among non-Hispanic (NH) White populations (3.08), followed by Hispanic (2.49) and NH Black individuals (2.46). Rural areas had higher mortality (3.23) than urban areas (2.56). The West (3.57) and Midwest (3.25) showed the greatest increases. While most deaths occurred in older adults (≥ 65 years), the most rapid increase was in younger adults (AAPC: 2.15%, p < 0.05).

Conclusion

Mortality from VHD and DM has risen significantly over 25 years, with persistent disparities. Men, NH Whites, and rural residents bear disproportionate burdens. Early diagnosis, timely intervention, and equitable care access are crucial to address these inequities.