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<p>Diabetic retinopathy (DR) and osteoporosis are prevalent complications in older adults with diabetes, yet their systemic link remains unclear. In this cross-sectional study of 1,004 adults aged ≥ 50&#xa0;years from NHANES 2005–2008, DR was assessed via retinal imaging and self-report, and femoral bone mineral density (BMD) was measured by DXA. Osteoporosis was independently associated with higher DR risk (OR = 1.90, 95% CI: 1.18–3.08), while higher BMD at all femoral sites was inversely associated with DR. These findings suggest shared systemic mechanisms between skeletal fragility and retinal microvascular injury, highlighting the potential value of bone health assessment for early identification of individuals at elevated DR risk and for integrated management of diabetic comorbidities.</p>

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Systematic association between bone mineral density, osteoporosis, and diabetic retinopathy in diabetic adults: new insights for comorbidity management

  • 期刊论文

  • 发表日期：

    2026年5月11日

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  • Chen Liu,
  • Jian Yin,
  • Yuliang Gu,
  • Yating Zhou

摘要

Diabetic retinopathy (DR) and osteoporosis are prevalent complications in older adults with diabetes, yet their systemic link remains unclear. In this cross-sectional study of 1,004 adults aged ≥ 50 years from NHANES 2005–2008, DR was assessed via retinal imaging and self-report, and femoral bone mineral density (BMD) was measured by DXA. Osteoporosis was independently associated with higher DR risk (OR = 1.90, 95% CI: 1.18–3.08), while higher BMD at all femoral sites was inversely associated with DR. These findings suggest shared systemic mechanisms between skeletal fragility and retinal microvascular injury, highlighting the potential value of bone health assessment for early identification of individuals at elevated DR risk and for integrated management of diabetic comorbidities.