Scholarlink

Purpose <p>This study aimed to investigate the association between fat mass and obesity-associated (<i>FTO</i>) gene Single Nucleotide Polymorphisms (SNPs) and the risk of type 2 diabetes (T2DM) in older Iranian adults, addressing the limited data available for older populations in the Middle East.</p> Methods <p>We analyzed 2,192 older adults from the Bushehr Elderly Health program in southern Iran. T2DM was defined using American Diabetes Association ADA criteria. The Illumina Global Screening Array was used to genotype <i>FTO</i> SNPs. In our analysis, 1,146 SNPs were examined for association with type 2 diabetes using generalized linear models under additive, dominant, and recessive models, controlling for age and sex, following quality control and linkage disequilibrium pruning. False discovery rate (FDR) correction was applied, with significance set at P<sub>FDR</sub> &lt; 0.05.</p> Results <p>Among 2,192 elderly participants, 34% had type 2 diabetes. Although none of the examined <i>FTO</i> SNPs showed a statistically significant association with T2DM after FDR correction, the lowest P value was observed for rs16952649 under the additive model (<i>P</i> ≈ 0.002). Known risk alleles, such as rs1421085 (C allele: 42% vs. 43% in Europeans) and rs9940128 (A allele: 45% vs. 44%), were present at similar frequencies to European populations. Ethnic-specific genetic patterns were also observed in the Bushehr cohort.</p> Conclusion <p>T2DM was not significantly associated with <i>FTO</i> variants, indicating context-dependent effects that were probably influenced by adiposity. The necessity of population-specific genetic research is highlighted by these findings.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Comprehensive SNP-based evaluation of fat mass and obesity-associated gene (FTO) variants and their association with type 2 diabetes: bushehr elderly health (BEH) program

  • 期刊论文

  • 发表日期：

    2025年9月22日

查看全文
  • Neda Alipour,
  • Farima Farsi,
  • Atefeh Amrollahi Bioky,
  • Nafiseh Tavasoli,
  • Mohammad Bidkhori,
  • Faezeh Sehatpour,
  • Kazem Khalagi,
  • Noushin Fahimfar,
  • Mahbube Ebrahimpur,
  • Afshin Ostovar,
  • Iraj Nabipour,
  • Mandana Hasanzad,
  • Bagher Larijani

摘要

Purpose

This study aimed to investigate the association between fat mass and obesity-associated (FTO) gene Single Nucleotide Polymorphisms (SNPs) and the risk of type 2 diabetes (T2DM) in older Iranian adults, addressing the limited data available for older populations in the Middle East.

Methods

We analyzed 2,192 older adults from the Bushehr Elderly Health program in southern Iran. T2DM was defined using American Diabetes Association ADA criteria. The Illumina Global Screening Array was used to genotype FTO SNPs. In our analysis, 1,146 SNPs were examined for association with type 2 diabetes using generalized linear models under additive, dominant, and recessive models, controlling for age and sex, following quality control and linkage disequilibrium pruning. False discovery rate (FDR) correction was applied, with significance set at PFDR < 0.05.

Results

Among 2,192 elderly participants, 34% had type 2 diabetes. Although none of the examined FTO SNPs showed a statistically significant association with T2DM after FDR correction, the lowest P value was observed for rs16952649 under the additive model (P ≈ 0.002). Known risk alleles, such as rs1421085 (C allele: 42% vs. 43% in Europeans) and rs9940128 (A allele: 45% vs. 44%), were present at similar frequencies to European populations. Ethnic-specific genetic patterns were also observed in the Bushehr cohort.

Conclusion

T2DM was not significantly associated with FTO variants, indicating context-dependent effects that were probably influenced by adiposity. The necessity of population-specific genetic research is highlighted by these findings.