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Background <p>Anxiety is a disorder treated through psychotherapy and/or pharmacotherapy. <i>Passiflora alata</i> Curtis is a herbal medicine used as a therapeutic alternative, although clinical evidence supporting its effectiveness in anxiety management is limited.</p> Objectives <p>This study aimed to evaluate the clinical, humanistic, and economic outcomes in participants with anxiety treated with <i>P. alata</i> extract.</p> Methods <p>This was an open-label, non-randomized, before-and-after experimental study. Inclusion criteria were: age ≥ 18 years and anxiety symptoms. The clinical outcome was assessed using the GAD-7 scale, comparing scores between baseline (t0) and the final follow-up (t3). The humanistic outcome was assessed using the TSQM, applied 15 days after treatment initiation and again at t3. The economic outcome consisted of analyzing direct treatment-related costs.</p> Results <p><i>P. alata</i> demonstrated clinical effectiveness in 29 participants (96.7%). TSQM results indicated a perceived improvement in health status within the first weeks. Regarding economic outcomes, differences were observed between the protocols that included <i>P. alata</i> and the conventional treatments offered by the Brazilian Unified Health System.</p> Conclusion <p>It was concluded that the use of <i>P. alata</i> extract for anxiety management is a potential therapeutic alternative for incorporation into the Brazilian Unified Health System.</p>

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Clinical, humanistic, and economic outcomes of Passiflora alata Curtis use in participants with mild to moderate anxiety: a non-randomized experimental study

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年2月4日

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  • Thatiane Bárbara de Barros,
  • Astrid Wiens,
  • Tiago Marques dos Reis

摘要

Background

Anxiety is a disorder treated through psychotherapy and/or pharmacotherapy. Passiflora alata Curtis is a herbal medicine used as a therapeutic alternative, although clinical evidence supporting its effectiveness in anxiety management is limited.

Objectives

This study aimed to evaluate the clinical, humanistic, and economic outcomes in participants with anxiety treated with P. alata extract.

Methods

This was an open-label, non-randomized, before-and-after experimental study. Inclusion criteria were: age ≥ 18 years and anxiety symptoms. The clinical outcome was assessed using the GAD-7 scale, comparing scores between baseline (t0) and the final follow-up (t3). The humanistic outcome was assessed using the TSQM, applied 15 days after treatment initiation and again at t3. The economic outcome consisted of analyzing direct treatment-related costs.

Results

P. alata demonstrated clinical effectiveness in 29 participants (96.7%). TSQM results indicated a perceived improvement in health status within the first weeks. Regarding economic outcomes, differences were observed between the protocols that included P. alata and the conventional treatments offered by the Brazilian Unified Health System.

Conclusion

It was concluded that the use of P. alata extract for anxiety management is a potential therapeutic alternative for incorporation into the Brazilian Unified Health System.