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<p>Zinc (Zn) and its alloys are considered promising biodegradable metallic materials for biomedical implants. However, the correlation between the dynamic degradation evolution of Zn and its biocompatibility remains unclear. This study evaluates the long-term degradation/corrosion behavior of pure Zn under dynamic immersion in Hank’s solution containing bovine serum albumin (BSA), and investigates the impact of its dynamic degradation evolution on cytocompatibilities of the representative human umbilical vein endothelial cells (HUVECs) and bone marrow mesenchymal stem cells (BMSCs). Degradation behavior results demonstrate that the dynamic fluidic medium led to speeding-up of the corrosion rate of Zn and exacerbation of the localized corrosion, with this phenomenon being more pronounced under influence of BSA. Correspondingly, the cells’ viability increased with prolonged immersion time under both static and dynamic conditions, alleviating a certain level of cytotoxicity initiated at an earlier stage. Nonetheless, as compared to the static cases the dynamic fluidic environments induced a poorer cell viability, although the BSA helped to offset this impact. Our findings provide not only new insights into better-understanding Zn-based biodegradable metals but also clarify the critical concern in their clinical translations, offering therefore important guidance for development of new biodegradable metallic medical implants.</p>

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Long-Term Evolving Dynamic Degradation-Associated Cytocompatibilities of Biodegradable Zinc for Biomedical Applications

  • 期刊论文

  • 发表日期：

    2025年8月11日

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  • Junyu Qian,
  • En Su,
  • Zhenhai Xie,
  • Jinlong Mao,
  • Yuanhao Wang,
  • Yingqi Chen,
  • Haotian Qin,
  • Guojiang Wan

摘要

Zinc (Zn) and its alloys are considered promising biodegradable metallic materials for biomedical implants. However, the correlation between the dynamic degradation evolution of Zn and its biocompatibility remains unclear. This study evaluates the long-term degradation/corrosion behavior of pure Zn under dynamic immersion in Hank’s solution containing bovine serum albumin (BSA), and investigates the impact of its dynamic degradation evolution on cytocompatibilities of the representative human umbilical vein endothelial cells (HUVECs) and bone marrow mesenchymal stem cells (BMSCs). Degradation behavior results demonstrate that the dynamic fluidic medium led to speeding-up of the corrosion rate of Zn and exacerbation of the localized corrosion, with this phenomenon being more pronounced under influence of BSA. Correspondingly, the cells’ viability increased with prolonged immersion time under both static and dynamic conditions, alleviating a certain level of cytotoxicity initiated at an earlier stage. Nonetheless, as compared to the static cases the dynamic fluidic environments induced a poorer cell viability, although the BSA helped to offset this impact. Our findings provide not only new insights into better-understanding Zn-based biodegradable metals but also clarify the critical concern in their clinical translations, offering therefore important guidance for development of new biodegradable metallic medical implants.