<p>High-entropy alloys (HEAs) and medium-entropy alloys (MEAs) represent a revolutionary class of materials characterized by their multielement composition, which imparts exceptional properties such as high strength, excellent corrosion resistance, and stability at elevated temperatures. Among these, the Ti–Zr–Hf–Nb–Ta alloy system stands out due to its promising potential for advanced applications. This research project aims to develop such alloys using wire arc additive manufacturing (WAAM), a cutting-edge technique known for its ability to produce large, complex metallic structures with minimal material waste. This study demonstrates the feasibility of producing a cored wire based on alloy Ti55–Zr17.5–Nb17.5–Hf5–Ta5. The fabricated wire was used as filler material for layer-by-layer deposition via the WAAM process using the TIG method. As a result, a six-layer sample of the medium-entropy alloy was obtained and subsequently analyzed using SEM, XRD, and EBSD techniques. Structural investigations and overall chemical analysis showed a single-phase structure and even distribution of all components respectively. The micromechanical properties showed tendential growth of microhardness from 354 to 417 HV from bottom to the top of the sample that directly correlates with the sample cooling rate gradient. Depending on this, Young’s modulus was also growing the same way from 88 to 92 GPa. The findings indicate that a higher content of Ta and Hf is required to achieve a high-entropy state. Additionally, the study concludes that the high quality of metal powders and incorporating a flux component in the form of halides into the wire core is necessary to prevent pore formation in the deposited layers.</p>