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Purpose of Review <p><i>ALDH1L2</i>, a mitochondrial enzyme belonging to the aldehyde dehydrogenase superfamily, plays a critical role in metabolic regulation and governs key biochemical pathways essential for cellular homeostasis. The function of ALDH1L2 contributes to the modulation of lipid metabolism, detoxification of reactive acetaldehyde and the maintenance of mitochondrial integrity, indicating its multifaceted roles. ALDH1L2 is a key enzyme in mitochondrial one-carbon folate metabolism, facilitating nucleotide synthesis and methionine regeneration. However biological significance of altered ALDH1L2 functions is not yet fully understood.</p> Recent Findings <p>Alterations in ALDH1L2 can potentially influence the development of various diseases. Indeed, variations in ALDH1L2 have been reported to be associated with metabolic diseases, liver disorders, and cancer. A preliminary study of patients with liver diseases identified a variant (c.337&#xa0;C &gt; G, p.Pro113Ala; rs199841702) in the <i>ALDH1L2</i> gene that is significantly associated with an increased risk of alcoholic liver cirrhosis.</p> Summary <p>A reduction in ALDH1L2 activity is believed to significantly impact ethanol metabolism, potentially due to the accumulation of harmful acetaldehyde. The intricate interplay of ALDH1L2 in various metabolic pathways underscores its importance as a key regulator of metabolic balance and disease, highlighting its role as a critical determinant of cellular homeostasis and adaptive responses. This review primarily aims to provide an overview of ALDH1L2 metabolism and does not seek to offer an in-depth discussion of potential therapeutic interventions targeting ALDH1L2.</p>

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Insights into the Multifaceted Roles and Pleiotropic Functions of ALDH1L2 with Implications in Gastrointestinal Diseases and Cancer

  • 期刊论文

  • 发表日期：

    2025年11月27日

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  • Partha Pratim Das,
  • Subhash Medhi,
  • Sangit Dutta,
  • Anjan Jyoti Talukdar,
  • Samudrala Gourinath

摘要

Purpose of Review

ALDH1L2, a mitochondrial enzyme belonging to the aldehyde dehydrogenase superfamily, plays a critical role in metabolic regulation and governs key biochemical pathways essential for cellular homeostasis. The function of ALDH1L2 contributes to the modulation of lipid metabolism, detoxification of reactive acetaldehyde and the maintenance of mitochondrial integrity, indicating its multifaceted roles. ALDH1L2 is a key enzyme in mitochondrial one-carbon folate metabolism, facilitating nucleotide synthesis and methionine regeneration. However biological significance of altered ALDH1L2 functions is not yet fully understood.

Recent Findings

Alterations in ALDH1L2 can potentially influence the development of various diseases. Indeed, variations in ALDH1L2 have been reported to be associated with metabolic diseases, liver disorders, and cancer. A preliminary study of patients with liver diseases identified a variant (c.337 C > G, p.Pro113Ala; rs199841702) in the ALDH1L2 gene that is significantly associated with an increased risk of alcoholic liver cirrhosis.

Summary

A reduction in ALDH1L2 activity is believed to significantly impact ethanol metabolism, potentially due to the accumulation of harmful acetaldehyde. The intricate interplay of ALDH1L2 in various metabolic pathways underscores its importance as a key regulator of metabolic balance and disease, highlighting its role as a critical determinant of cellular homeostasis and adaptive responses. This review primarily aims to provide an overview of ALDH1L2 metabolism and does not seek to offer an in-depth discussion of potential therapeutic interventions targeting ALDH1L2.