Purpose of Review <p>Malnutrition, sarcopenia, and frailty are highly prevalent in patients with cirrhosis awaiting liver transplantation (LT) and are strongly associated with waitlist dropout, postoperative complications, and mortality. Nutritional prehabilitation has emerged as a feasible strategy to preserve muscle mass, improve functional capacity, and optimize transplant readiness. The aim of this review was to operationalize nutritional prehabilitation across the full continuum of care in patients with cirrhosis awaiting LT.</p> Recent Findings <p>Prehabilitation has emerged as a feasible and safe strategy in patients with cirrhosis awaiting LT, but the nutritional pillar remains relatively understudied. Established nutrition guidelines in cirrhosis provide a basis for nutritional prehabilitation but do not provide a structured approach to nutritional prehabilitation across the frequent transitions between outpatient, inpatient, and critical care settings.</p> Summary <p>Nutritional prehabilitation should be framed as a dynamic, continuous process rather than a fixed intervention. This review provides clinicians with a practical, setting-specific roadmap to optimize nutritional care throughout the LT waitlist journey.</p>

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Nutritional Prehabilitation Across the Continuum of Care in Patients with Cirrhosis Awaiting Liver Transplantation

  • Christofer Cruz,
  • Danielle Picard,
  • Marta E. Berguido de la Guardia,
  • Alejandro Fabrega Gerbaud,
  • Puneeta Tandon,
  • Carla P. Venegas

摘要

Purpose of Review

Malnutrition, sarcopenia, and frailty are highly prevalent in patients with cirrhosis awaiting liver transplantation (LT) and are strongly associated with waitlist dropout, postoperative complications, and mortality. Nutritional prehabilitation has emerged as a feasible strategy to preserve muscle mass, improve functional capacity, and optimize transplant readiness. The aim of this review was to operationalize nutritional prehabilitation across the full continuum of care in patients with cirrhosis awaiting LT.

Recent Findings

Prehabilitation has emerged as a feasible and safe strategy in patients with cirrhosis awaiting LT, but the nutritional pillar remains relatively understudied. Established nutrition guidelines in cirrhosis provide a basis for nutritional prehabilitation but do not provide a structured approach to nutritional prehabilitation across the frequent transitions between outpatient, inpatient, and critical care settings.

Summary

Nutritional prehabilitation should be framed as a dynamic, continuous process rather than a fixed intervention. This review provides clinicians with a practical, setting-specific roadmap to optimize nutritional care throughout the LT waitlist journey.