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Purpose of Review <p>Ultra-short bowel syndrome (USBS) is a rare and severe form of short bowel syndrome (SBS), characterized by a markedly reduced length of functional small intestine (less than 50&#xa0;cm of small bowel remaining). This condition leads to profound malabsorption, fluid and electrolyte imbalances, and significant nutritional deficiencies, often necessitating long-term home parenteral nutrition (HPN).</p> Recent Findings <p>USBS may arise from diverse etiologies, including congenital anomalies in children, ischemic or inflammatory diseases in adults, and USBS resulting from trauma or injury to the vascular supply during surgery. Despite advances in HPN formulations, surgical techniques, and pharmacologic agents such as teduglutide, many patients remain HPN-dependent. Multidisciplinary intestinal rehabilitation is a key strategy to promote intestinal adaptation and reduce complications.</p> Summary <p>This review synthesizes current literature on epidemiology, clinical presentation, and management of USBS in pediatric and adult populations. Additionally, we present a single-center case series of adults with USBS managed through a specialized HPN program. These findings highlight the need for tailored, interdisciplinary care to optimize outcomes in this complex condition.</p>

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Ultra Short Bowel Syndrome: Living on the Edge

  • 期刊论文

  • 发表日期：

    2025年5月31日

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  • Osman Mohamed Elfadil,
  • Ryan T. Hurt,
  • Manpreet S. Mundi,
  • Bradley R. Salonen,
  • Sara L. Bonnes,
  • Robert G. Martindale,
  • Jithinraj Edakkanambeth Varayil

摘要

Purpose of Review

Ultra-short bowel syndrome (USBS) is a rare and severe form of short bowel syndrome (SBS), characterized by a markedly reduced length of functional small intestine (less than 50 cm of small bowel remaining). This condition leads to profound malabsorption, fluid and electrolyte imbalances, and significant nutritional deficiencies, often necessitating long-term home parenteral nutrition (HPN).

Recent Findings

USBS may arise from diverse etiologies, including congenital anomalies in children, ischemic or inflammatory diseases in adults, and USBS resulting from trauma or injury to the vascular supply during surgery. Despite advances in HPN formulations, surgical techniques, and pharmacologic agents such as teduglutide, many patients remain HPN-dependent. Multidisciplinary intestinal rehabilitation is a key strategy to promote intestinal adaptation and reduce complications.

Summary

This review synthesizes current literature on epidemiology, clinical presentation, and management of USBS in pediatric and adult populations. Additionally, we present a single-center case series of adults with USBS managed through a specialized HPN program. These findings highlight the need for tailored, interdisciplinary care to optimize outcomes in this complex condition.