Purpose of Review <p>To discuss the nutritional aspects and a practical approach to navigating a gluten-free diet for celiac disease.</p> Recent Findings <p>Celiac disease and navigating the gluten-free diet can present a variety of difficulties for patients and families faced with this predicament. A comprehensive and practical review and approach to navigating a gluten-free diet in children is needed to aid clinicians in shepherding families through adhering to a gluten-free lifestyle. </p> Summary <p>Celiac disease is an autoimmune enteropathy that occurs in genetically predisposed individuals. Screening is with serum celiac disease specific antibodies, most commonly anti-tissue transglutaminase IgA (when IgA sufficiency has been assured with normal total serum IgA). Diagnosis is via upper endoscopy with biopsies of the small intestine that show intraepithelial lymphocytosis, villous blunting, and crypt hyperplasia. Treatment is a strict lifelong gluten-free (GF) diet- avoidance of wheat, barley, and rye. Adoption of a gluten-free diet can be difficult for a variety of reasons and education and counseling is best performed with the help of a registered dietitian. Continued monitoring of patients for nutritional deficiencies and ongoing symptoms and growth in children is paramount in management of pediatric celiac disease. </p>