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Introduction <p>Macular telangiectasia (MacTel) is a neurodegenerative retinal disease with progressive visual decline. Contemporary prevalence estimates based on diverse patient populations are required to better understand this condition.</p> Methods <p>This was a retrospective cross-sectional study conducted at Kaiser Permanente Southern California that included patients over 18&#xa0;years of age who underwent ophthalmology or optometry evaluations between January 1, 2020 and September 1, 2025. The primary outcome was prevalence of macular telangiectasia (MacTel) based on clinician diagnoses. Secondary outcomes included mean visual acuity and distribution of visual acuity (≥ 20/25, ≥ 20/40, ≥ 20/80, ≥ 20/200, and &lt; 20/200) analyzed separately for all eyes as well as better- and worse-seeing eyes. Logistic regressions were performed to compare prevalence between different demographic groups with calculation of adjusted prevalence rates and adjusted odds ratios (aOR).</p> Results <p>Of 1,927,300 patients who had seen an eye care provider during the study period, 1224 were diagnosed with MacTel (prevalence 0.06%). The mean age of patients with MacTel was 65.5&#xa0;years (SD 11.2). Compared to those between the ages of 18–39 (adjusted prevalence 0.01%), MacTel was more common in the 40–59 (adjusted prevalence 0.05%, OR 9.61 95%&#xa0;CI 6.39–14.45, <i>p</i> &lt; 0.01) and ≥ 60 age groups (adjusted prevalence 0.10%, OR 20.36 95%&#xa0;CI 13.66–30.34, <i>p</i> &lt; 0.001). MacTel was more common in women (adjusted prevalence 0.04%, OR 1.31 95%&#xa0;CI 1.17–1.47) and less common in non-white patients, with all comparisons except with Hispanic patients reaching statistical significance (white adjusted prevalence 0.05%, reference group; Asian adjusted prevalence 0.03%, OR 0.69, 95%&#xa0;CI 0.57–0.84, <i>p</i> &lt; 0.001; Black adjusted prevalence 0.02%, OR 0.55 95%&#xa0;CI 0.43–0.71, <i>p</i> &lt; 0.001; Hispanic adjusted prevalence 0.04%, OR 0.93, 95%&#xa0;CI 0.81–1.06, <i>p</i> = 0.27; other/unknown adjusted prevalence 0.03%, OR 0.74, 95%&#xa0;CI 0.58–0.95, <i>p</i> = 0.02). Mean visual acuity was 0.38&#xa0;logMAR (~ 20/50) for all eyes, 0.23&#xa0;logMAR (~ 20/40) in the better-seeing eye, and 0.53&#xa0;logMAR (~ 20/70) in the worse-seeing eye. Among all eyes, 26.8% had VA ≥ 20/25, 58.3% ≥ 20/40, 85.0% ≥ 20/80, 94.6% ≥ 20/200, and 5.4% &lt; 20/200.</p> Conclusion <p>MacTel was identified in 0.06% of adults in this large diverse USA-based cohort. Visual acuity was symmetric between eyes, with an average of 20/40 in better-seeing eyes. These findings provide contemporary real-world data to inform clinical understanding and research. Demographic differences in disease prevalence highlight the need to ensure diverse patient representation in future studies and clinical outreach.</p>

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Prevalence and Visual Acuity Characteristics of Patients with Macular Telangiectasia

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  • 发表日期：

    2026年7月14日

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  • Danah A. Younis,
  • Daniel X. Chen,
  • Siyan Chen,
  • AnMarie Nguyen,
  • Bobeck S. Modjtahedi

摘要

Introduction

Macular telangiectasia (MacTel) is a neurodegenerative retinal disease with progressive visual decline. Contemporary prevalence estimates based on diverse patient populations are required to better understand this condition.

Methods

This was a retrospective cross-sectional study conducted at Kaiser Permanente Southern California that included patients over 18 years of age who underwent ophthalmology or optometry evaluations between January 1, 2020 and September 1, 2025. The primary outcome was prevalence of macular telangiectasia (MacTel) based on clinician diagnoses. Secondary outcomes included mean visual acuity and distribution of visual acuity (≥ 20/25, ≥ 20/40, ≥ 20/80, ≥ 20/200, and < 20/200) analyzed separately for all eyes as well as better- and worse-seeing eyes. Logistic regressions were performed to compare prevalence between different demographic groups with calculation of adjusted prevalence rates and adjusted odds ratios (aOR).

Results

Of 1,927,300 patients who had seen an eye care provider during the study period, 1224 were diagnosed with MacTel (prevalence 0.06%). The mean age of patients with MacTel was 65.5 years (SD 11.2). Compared to those between the ages of 18–39 (adjusted prevalence 0.01%), MacTel was more common in the 40–59 (adjusted prevalence 0.05%, OR 9.61 95% CI 6.39–14.45, p < 0.01) and ≥ 60 age groups (adjusted prevalence 0.10%, OR 20.36 95% CI 13.66–30.34, p < 0.001). MacTel was more common in women (adjusted prevalence 0.04%, OR 1.31 95% CI 1.17–1.47) and less common in non-white patients, with all comparisons except with Hispanic patients reaching statistical significance (white adjusted prevalence 0.05%, reference group; Asian adjusted prevalence 0.03%, OR 0.69, 95% CI 0.57–0.84, p < 0.001; Black adjusted prevalence 0.02%, OR 0.55 95% CI 0.43–0.71, p < 0.001; Hispanic adjusted prevalence 0.04%, OR 0.93, 95% CI 0.81–1.06, p = 0.27; other/unknown adjusted prevalence 0.03%, OR 0.74, 95% CI 0.58–0.95, p = 0.02). Mean visual acuity was 0.38 logMAR (~ 20/50) for all eyes, 0.23 logMAR (~ 20/40) in the better-seeing eye, and 0.53 logMAR (~ 20/70) in the worse-seeing eye. Among all eyes, 26.8% had VA ≥ 20/25, 58.3% ≥ 20/40, 85.0% ≥ 20/80, 94.6% ≥ 20/200, and 5.4% < 20/200.

Conclusion

MacTel was identified in 0.06% of adults in this large diverse USA-based cohort. Visual acuity was symmetric between eyes, with an average of 20/40 in better-seeing eyes. These findings provide contemporary real-world data to inform clinical understanding and research. Demographic differences in disease prevalence highlight the need to ensure diverse patient representation in future studies and clinical outreach.