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Introduction <p>To determine whether macular involvement (on or off) at the time of rhegmatogenous retinal detachment (RRD) influences postoperative stereopsis and to explore factors associated with vision-related quality of life (VR-QoL).</p> Methods <p>In this prospective, single-centre observational cohort study conducted at the University Hospital of Tours, patients who underwent successful unilateral pars plana vitrectomy (PPV) for RRD were examined for 6 to 18&#xa0;months postoperatively between June 2024 and March 2025. Surgical success was defined as anatomical reattachment at 3&#xa0;months postoperatively. The following data were collected: intraoperative macular involvement, diplopia (orthoptic exam and optotype frame test), stereoacuity (The Netherlands Organization test), distance monocular best-corrected visual acuity, metamorphopsia (M-CHARTS), aniseikonia (New Aniseikonia Test), central retinal thickness and ellipsoid zone integrity on optical coherence tomography, retinal ghost vessels (autofluorescence), and VR-QoL assessed using the National Eye Institute Visual Function Questionnaire-25 (NEI VFQ-25). Univariate analysis was performed to assess stereopsis, and factors associated with VR-QoL were investigated using multivariate linear regressions.</p> Results <p>Forty-five patients were included [median age (range): 67 (46–82)&#xa0;years; women: 18 (40%), men: 27 (60%)]. Median duration from RRD repair and assessment was 10 (range 6–18)&#xa0;months. Stereoacuity was significantly worse in the macula-off group than in the macula-on group (<i>p</i> = 0.045). Multivariate analysis revealed that diplopia correlated negatively with the NEI VFQ-25 composite score (<i>p</i> = 0.004). No other variable showed any significant association with the NEI VFQ-25 composite score or its subscales (<i>p</i> &gt; 0.05).</p> Conclusion <p>Postoperative stereopsis is significantly reduced in patients with macula-off RRD compared to those with macula-on RDD despite successful anatomical repair. However, neither stereopsis loss nor monocular qualitative or quantitative visual loss was significantly associated with VR-QoL in this cohort. Binocular diplopia, regardless of its mechanism, particularly affects VR-QoL, highlighting the importance of tailored postoperative assessment in patients with RRD.</p>

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Stereopsis and Vision-Related Quality of Life After Pars Plana Vitrectomy for Rhegmatogenous Retinal Detachment: A Prospective Cohort Study

  • 期刊论文

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  • 发表日期：

    2026年2月19日

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  • Kamil Gazizov,
  • Jeremy Pasco,
  • Jean-Baptiste Ducloyer,
  • Marie-Thérèse Marotte,
  • Lucile Durand,
  • Léa Dormegny,
  • Sophie Arsène,
  • Raoul Kanav Khanna

摘要

Introduction

To determine whether macular involvement (on or off) at the time of rhegmatogenous retinal detachment (RRD) influences postoperative stereopsis and to explore factors associated with vision-related quality of life (VR-QoL).

Methods

In this prospective, single-centre observational cohort study conducted at the University Hospital of Tours, patients who underwent successful unilateral pars plana vitrectomy (PPV) for RRD were examined for 6 to 18 months postoperatively between June 2024 and March 2025. Surgical success was defined as anatomical reattachment at 3 months postoperatively. The following data were collected: intraoperative macular involvement, diplopia (orthoptic exam and optotype frame test), stereoacuity (The Netherlands Organization test), distance monocular best-corrected visual acuity, metamorphopsia (M-CHARTS), aniseikonia (New Aniseikonia Test), central retinal thickness and ellipsoid zone integrity on optical coherence tomography, retinal ghost vessels (autofluorescence), and VR-QoL assessed using the National Eye Institute Visual Function Questionnaire-25 (NEI VFQ-25). Univariate analysis was performed to assess stereopsis, and factors associated with VR-QoL were investigated using multivariate linear regressions.

Results

Forty-five patients were included [median age (range): 67 (46–82) years; women: 18 (40%), men: 27 (60%)]. Median duration from RRD repair and assessment was 10 (range 6–18) months. Stereoacuity was significantly worse in the macula-off group than in the macula-on group (p = 0.045). Multivariate analysis revealed that diplopia correlated negatively with the NEI VFQ-25 composite score (p = 0.004). No other variable showed any significant association with the NEI VFQ-25 composite score or its subscales (p > 0.05).

Conclusion

Postoperative stereopsis is significantly reduced in patients with macula-off RRD compared to those with macula-on RDD despite successful anatomical repair. However, neither stereopsis loss nor monocular qualitative or quantitative visual loss was significantly associated with VR-QoL in this cohort. Binocular diplopia, regardless of its mechanism, particularly affects VR-QoL, highlighting the importance of tailored postoperative assessment in patients with RRD.