Scholarlink

Introduction <p>To investigate distinct neurodegeneration mechanisms in pachychoroid pigment epitheliopathy (PPE) versus age-related macular degeneration (AMD) using quantitative optical coherence tomography (OCT) with age-matched controls.</p> Methods <p>This cross-sectional study of 184 subjects included 50 age-matched controls (25 young: 47–63&#xa0;years; 25 elderly: 67–83&#xa0;years), 57 PPE patients (47–63&#xa0;years), 39 AMD drusen patients (64–80&#xa0;years), and 38 AMD reticular pseudodrusen patients (67–83&#xa0;years). Primary outcomes included ganglion cell layer–inner plexiform layer (GCL-IPL) thickness, subfoveal choroidal thickness, and choroidal volume using swept-source OCT.</p> Results <p>All pathologic conditions showed significant neurodegeneration versus age-matched controls (<i>p</i> &lt; 0.001). PPE demonstrated choroidal thickening (410.5 ± 32.9&#xa0;μm vs. 306.0 ± 10.8&#xa0;μm controls) with inverse choroidal–neural correlations (<i>r</i> = −0.52 to −0.61, <i>p</i> &lt; 0.001). AMD variants showed choroidal thinning (187–238&#xa0;μm vs. 277&#xa0;μm elderly controls) with positive correlations (drusen: <i>r</i> = +0.43, <i>p</i> = 0.006; RPD: <i>r</i> = +0.68, <i>p</i> &lt; 0.001).</p> Conclusions <p>Two distinct pathways cause neurodegeneration: compressive (PPE: choroidal thickening → choriocapillaris compression → neurodegeneration) and ischemic (AMD: choroidal thinning → hypoperfusion → neurodegeneration).</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Distinct Pathogenic Mechanisms of Neurodegeneration in Pachychoroid Pigment Epitheliopathy Versus Intermediate Age-Related Macular Degeneration

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年9月24日

查看全文
  • Pasquale Viggiano,
  • Lorenzo Accurso Tagano,
  • Roberta Binetti,
  • Stefania De Leonardis,
  • Marco Carella,
  • Giulia Ribezzi,
  • Alba Chiara Termite,
  • Maria Grazia Pignataro,
  • Stefano Dore,
  • Federica Evangelista,
  • Paolo Evangelista,
  • Cristiana Iaculli,
  • Giovanni Alessio,
  • Francesco Boscia

摘要

Introduction

To investigate distinct neurodegeneration mechanisms in pachychoroid pigment epitheliopathy (PPE) versus age-related macular degeneration (AMD) using quantitative optical coherence tomography (OCT) with age-matched controls.

Methods

This cross-sectional study of 184 subjects included 50 age-matched controls (25 young: 47–63 years; 25 elderly: 67–83 years), 57 PPE patients (47–63 years), 39 AMD drusen patients (64–80 years), and 38 AMD reticular pseudodrusen patients (67–83 years). Primary outcomes included ganglion cell layer–inner plexiform layer (GCL-IPL) thickness, subfoveal choroidal thickness, and choroidal volume using swept-source OCT.

Results

All pathologic conditions showed significant neurodegeneration versus age-matched controls (p < 0.001). PPE demonstrated choroidal thickening (410.5 ± 32.9 μm vs. 306.0 ± 10.8 μm controls) with inverse choroidal–neural correlations (r = −0.52 to −0.61, p < 0.001). AMD variants showed choroidal thinning (187–238 μm vs. 277 μm elderly controls) with positive correlations (drusen: r = +0.43, p = 0.006; RPD: r = +0.68, p < 0.001).

Conclusions

Two distinct pathways cause neurodegeneration: compressive (PPE: choroidal thickening → choriocapillaris compression → neurodegeneration) and ischemic (AMD: choroidal thinning → hypoperfusion → neurodegeneration).