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Introduction <p>We investigated the relationship between optical coherence tomography (OCT) angiography (OCTA)-derived vascular parameters, central visual field (10-2 VF), ganglion cell complex (GCC), and retinal nerve fiber layer (RNFL) thickness in patients with advanced glaucoma.</p> Methods <p>This retrospective, cross-sectional study included 28 eyes of 23 patients with advanced glaucoma (VF mean deviation [MD] worse than −&#xa0;12&#xa0;dB on 24-2 testing). All participants underwent comprehensive ophthalmic examinations, OCT, OCTA, and 10-2 VF tests. Pearson’s correlation was used to assess relationships between structural, functional, and vascular parameters.</p> Results <p>Statistically significant positive correlations were found between GCC thickness and 10-2 VF MD (<i>r</i> = 0.529, <i>p</i> = 0.005), and between parafoveal superficial capillary plexus vessel density (SCP-VD) and 10-2 VF MD (<i>r</i> = 0.549, <i>p</i> = 0.002). Macular SCP vessel area density showed a positive correlation with RNFL thickness (<i>r</i> = 0.429, <i>p</i> = 0.036). Mean vessel length in the optic nerve head layer exhibited a negative correlation with 10-2 VF MD (<i>r</i> = −&#xa0;0.528, <i>p</i> = 0.003). Quadrant-wise analysis revealed positive associations between SCP-VD and both GCC (<i>r</i> = 0.409, <i>p</i> = 0.038) and RNFL thickness (<i>r</i> = 0.410, <i>p</i> = 0.047) in the superior hemifield, and between deep capillary plexus vessel density and RNFL thickness (<i>r</i> = 0.533, <i>p</i> = 0.007) in the inferior hemifield.</p> Conclusion <p>Parafoveal SCP-VD and GCC thickness, due to their significant correlations with 10-2 VF MD, may serve as surrogate markers for monitoring central visual function and disease progression in advanced glaucoma, particularly when reliable VF testing is not feasible.</p>

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Correlating 10-2 Visual Field Loss with Structural and Angiographic Parameters in Advanced Glaucoma

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年7月3日

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  • Kübra Atay Dinçer,
  • Metehan Karaatlı,
  • Onur Özalp,
  • Tülay Şimşek,
  • Monisha Esther Nongpiur,
  • Eray Atalay

摘要

Introduction

We investigated the relationship between optical coherence tomography (OCT) angiography (OCTA)-derived vascular parameters, central visual field (10-2 VF), ganglion cell complex (GCC), and retinal nerve fiber layer (RNFL) thickness in patients with advanced glaucoma.

Methods

This retrospective, cross-sectional study included 28 eyes of 23 patients with advanced glaucoma (VF mean deviation [MD] worse than − 12 dB on 24-2 testing). All participants underwent comprehensive ophthalmic examinations, OCT, OCTA, and 10-2 VF tests. Pearson’s correlation was used to assess relationships between structural, functional, and vascular parameters.

Results

Statistically significant positive correlations were found between GCC thickness and 10-2 VF MD (r = 0.529, p = 0.005), and between parafoveal superficial capillary plexus vessel density (SCP-VD) and 10-2 VF MD (r = 0.549, p = 0.002). Macular SCP vessel area density showed a positive correlation with RNFL thickness (r = 0.429, p = 0.036). Mean vessel length in the optic nerve head layer exhibited a negative correlation with 10-2 VF MD (r = − 0.528, p = 0.003). Quadrant-wise analysis revealed positive associations between SCP-VD and both GCC (r = 0.409, p = 0.038) and RNFL thickness (r = 0.410, p = 0.047) in the superior hemifield, and between deep capillary plexus vessel density and RNFL thickness (r = 0.533, p = 0.007) in the inferior hemifield.

Conclusion

Parafoveal SCP-VD and GCC thickness, due to their significant correlations with 10-2 VF MD, may serve as surrogate markers for monitoring central visual function and disease progression in advanced glaucoma, particularly when reliable VF testing is not feasible.