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Introduction <p>Various acupuncture techniques are widely applied in clinics for pain control and dysfunction relief in patients with knee osteoarthritis (KOA). The purpose of this trial was to investigate whether the different acupuncture techniques were more effective in treating joint pain and dysfunction than were sham acupuncture or drug treatment in patients with KOA and to determine the differences in efficacy among them.</p> Methods <p>In this multi-center, single-blind, randomized, controlled trial, participants were randomly assigned to the manual acupuncture (MA), electroacupuncture (EA), warm-needling acupuncture (WA), mild moxibustion (MM), sham acupuncture (SA), or drug treatment (Celebrex) groups. Each participant in the above groups received individual treatments for 4 consecutive weeks. The primary outcome measures included the visual analog scale score (VAS) and the physical function score of the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC).</p> Results <p>Compared with the SA group, the acupuncture technique groups (MA, EA, WA, and MM) had markedly lower patient VAS scores (− 0.61; 95% CI − 1.09 to − 0.13;<i> P</i> = 0.01) and lower WOMAC physical function scores (− 13.84; 95% CI − 21.14 to − 6.54; <i>P</i> &lt; 0.01). Compared with Celebrex, EA had a significant advantage in reducing the VAS score (1.14; 95% CI 0.55 to 1.72; <i>P</i> &lt; 0.01) and WOMAC physical function score (14.81; 95% CI 5.69 to 23.93; <i>P</i> &lt; 0.01).</p> Conclusions <p>The observed acupuncture techniques effectively relieve pain and ameliorate knee joint dysfunction in patients with KOA. EA is the most effective method of alleviating pain intensity in treating KOA.</p> Trial registration <p>The trial was registered on ClinicalTrials.gov (NCT03563690).</p>

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Efficacy of Different Acupuncture Techniques for Pain and Dysfunction in Patients with Knee Osteoarthritis: A Randomized Controlled Trial

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年2月17日

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  • Jing Sun,
  • Yi Liang,
  • Kai-Tao Luo,
  • Xiao-Mei Shao,
  • Ming-Qi Tu,
  • Xiao-Ting Wu,
  • Fang Liu,
  • Xin-Wei Li,
  • Yi-Dan Chen,
  • Qi-Fei Zhang,
  • Cong-Hua Ji,
  • Rong-Rong Li,
  • Xiao-Yu Li,
  • Fu Xu,
  • Jian-Qiao Fang

摘要

Introduction

Various acupuncture techniques are widely applied in clinics for pain control and dysfunction relief in patients with knee osteoarthritis (KOA). The purpose of this trial was to investigate whether the different acupuncture techniques were more effective in treating joint pain and dysfunction than were sham acupuncture or drug treatment in patients with KOA and to determine the differences in efficacy among them.

Methods

In this multi-center, single-blind, randomized, controlled trial, participants were randomly assigned to the manual acupuncture (MA), electroacupuncture (EA), warm-needling acupuncture (WA), mild moxibustion (MM), sham acupuncture (SA), or drug treatment (Celebrex) groups. Each participant in the above groups received individual treatments for 4 consecutive weeks. The primary outcome measures included the visual analog scale score (VAS) and the physical function score of the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC).

Results

Compared with the SA group, the acupuncture technique groups (MA, EA, WA, and MM) had markedly lower patient VAS scores (− 0.61; 95% CI − 1.09 to − 0.13; P = 0.01) and lower WOMAC physical function scores (− 13.84; 95% CI − 21.14 to − 6.54; P < 0.01). Compared with Celebrex, EA had a significant advantage in reducing the VAS score (1.14; 95% CI 0.55 to 1.72; P < 0.01) and WOMAC physical function score (14.81; 95% CI 5.69 to 23.93; P < 0.01).

Conclusions

The observed acupuncture techniques effectively relieve pain and ameliorate knee joint dysfunction in patients with KOA. EA is the most effective method of alleviating pain intensity in treating KOA.

Trial registration

The trial was registered on ClinicalTrials.gov (NCT03563690).