Scholarlink

Introduction <p>The hospitalization burden of human metapneumovirus (HMPV) in Spain was estimated assessing disease manifestations and risk factors to guide future vaccine strategies.</p> Methods <p>This study was a&#xa0;retrospective analysis of Spain's National Hospital Data System (CMBD) from 2016–2023,&#xa0;performed&#xa0;using ICD-10-CM diagnosis codes, with age-stratified analyses for children under 6 years and adults over 60 years, assessing comorbidities and associated mortality risks.</p> Results <p>A total of 4824 hospitalizations were identified; 75% in children, 16% in older adults. Bronchiolitis dominated in children while pneumonia was most common in older adults. Overall annual hospitalization rate was 18.70 hospitalizations per 100,000 in children up to 5&#xa0;years old, and the annual hospitalization rate was 0.79 hospitalizations per 100,000 in adults over 60&#xa0;years, Hospital costs totaled over €22 million, and, beyond this overall burden, expenditures showed a significant year-on-year increasing trend. There were 2 deaths among children &lt; 6&#xa0;years, 18 in individuals between 16 and 59&#xa0;years and 74 in adults over 60&#xa0;years old, reaching a case fatality rate of 9.65% in adults, with higher risk associated with kidney failure, liver disease, and cancer.</p> Conclusions <p>HMPV poses a significant burden on vulnerable groups in Spain. Despite underdiagnosis, rising cases post-COVID highlight the need for targeted prevention. These findings offer a foundation for public health planning and vaccine prioritization.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Epidemiological Burden and Hospitalization Trends of Human Metapneumovirus in Spain (2016–2023): A Retrospective Study

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年3月7日

查看全文
  • Oscar Brochado-Kith,
  • Ruth Gil-Prieto,
  • Angel Gil-de-Miguel

摘要

Introduction

The hospitalization burden of human metapneumovirus (HMPV) in Spain was estimated assessing disease manifestations and risk factors to guide future vaccine strategies.

Methods

This study was a retrospective analysis of Spain's National Hospital Data System (CMBD) from 2016–2023, performed using ICD-10-CM diagnosis codes, with age-stratified analyses for children under 6 years and adults over 60 years, assessing comorbidities and associated mortality risks.

Results

A total of 4824 hospitalizations were identified; 75% in children, 16% in older adults. Bronchiolitis dominated in children while pneumonia was most common in older adults. Overall annual hospitalization rate was 18.70 hospitalizations per 100,000 in children up to 5 years old, and the annual hospitalization rate was 0.79 hospitalizations per 100,000 in adults over 60 years, Hospital costs totaled over €22 million, and, beyond this overall burden, expenditures showed a significant year-on-year increasing trend. There were 2 deaths among children < 6 years, 18 in individuals between 16 and 59 years and 74 in adults over 60 years old, reaching a case fatality rate of 9.65% in adults, with higher risk associated with kidney failure, liver disease, and cancer.

Conclusions

HMPV poses a significant burden on vulnerable groups in Spain. Despite underdiagnosis, rising cases post-COVID highlight the need for targeted prevention. These findings offer a foundation for public health planning and vaccine prioritization.