Scholarlink

Introduction <p>We aimed to investigate risk factors for mortality among older adults (≥ 75&#xa0;years) with hospital-acquired bloodstream infections (HA-BSI) in the intensive care unit (ICU).</p> Methods <p>We included patients aged ≥ 75&#xa0;years with HA-BSI in ICU from the EUROBACT-2 cohort (2019–2021). Univariable and multivariable analyses were conducted to identify predictors of 28-day mortality.</p> Results <p>The cohort included 563 patients (median age 80, 39% women). Mortality at 28&#xa0;day was 50%. Factors associated with mortality in multivariate analysis were admission due to COVID-19, failure to achieve source control, and higher SOFA. Among older adults with Gram-negative BSI, corticosteroid administration for septic shock was an additional factor. Among functionally independent patients, age itself was not associated with mortality.</p> Conclusions <p>HA-BSI in older adults in ICU are associated with high mortality. Inadequate source control is a significant modifiable risk factor. The use of corticosteroids in ICU management of older adults should be further investigated.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Risk Factors for Mortality Among Older Adults with Hospital-Acquired Bloodstream Infections in the Intensive Care Unit: A Multicenter Cohort Study

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年1月11日

查看全文
  • Tomer Hoffman,
  • Ili Margalit,
  • Alexis Tabah,
  • Stéphane Ruckly,
  • François Barbier,
  • Pierre Singer,
  • Jean-François Timsit,
  • Virginie Prendki,
  • Nasreen Hassoun-Kheir,
  • Niccolò Buetti,
  • Dafna Yahav

摘要

Introduction

We aimed to investigate risk factors for mortality among older adults (≥ 75 years) with hospital-acquired bloodstream infections (HA-BSI) in the intensive care unit (ICU).

Methods

We included patients aged ≥ 75 years with HA-BSI in ICU from the EUROBACT-2 cohort (2019–2021). Univariable and multivariable analyses were conducted to identify predictors of 28-day mortality.

Results

The cohort included 563 patients (median age 80, 39% women). Mortality at 28 day was 50%. Factors associated with mortality in multivariate analysis were admission due to COVID-19, failure to achieve source control, and higher SOFA. Among older adults with Gram-negative BSI, corticosteroid administration for septic shock was an additional factor. Among functionally independent patients, age itself was not associated with mortality.

Conclusions

HA-BSI in older adults in ICU are associated with high mortality. Inadequate source control is a significant modifiable risk factor. The use of corticosteroids in ICU management of older adults should be further investigated.