Scholarlink

<p>Recently targeted alpha therapy (TAT) using actinium-225 (<sup>225</sup>Ac) has been of interest due to impressive clinical results. The <sup>225</sup>Ac radioisotope decays into bismuth-209 (<sup>209</sup>Bi) by emitting four alpha and two beta particles with a half-life of 9.9&#xa0;days, which is appropriate for medical applications. Several research groups reported that ample quantities of <sup>225</sup>Ac could be produced via spallation of thorium-232 (<sup>232</sup>Th) with energetic protons, having less than 0.1% of actinium-227 (<sup>227</sup>Ac) as a byproduct. In order to reduce the <sup>227</sup>Ac/<sup>225</sup>Ac ratio, IRIS will employ the energy range of 40–70&#xa0;MeV protons irradiated onto the Th target. The target has a structure of 30&#xa0;mm diameter and a thickness of 3&#xa0;mm ThO<sub>2</sub> with a 0.5&#xa0;mm-thick aluminum front window, which securely seals the target material. To ensure the stability and safety of thorium targets under high-power beam conditions, a packaging design for the protective Al layer of thorium targets will be adapted and accompanied by detailed mechanical and thermal analyses.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Design of a ThO2 target for actinium-225 development at IRIS

  • 期刊论文

  • 发表日期：

    2026年4月30日

查看全文
  • Jaehong Kim,
  • Bum Sik Park,
  • Yeong Heum Yeon,
  • Hyoun Woo Jung,
  • Beom Yeol Baek,
  • In Seok Hong,
  • Hee Joong Yim,
  • Jin Ho Lee,
  • Taeksu Shin

摘要

Recently targeted alpha therapy (TAT) using actinium-225 (225Ac) has been of interest due to impressive clinical results. The 225Ac radioisotope decays into bismuth-209 (209Bi) by emitting four alpha and two beta particles with a half-life of 9.9 days, which is appropriate for medical applications. Several research groups reported that ample quantities of 225Ac could be produced via spallation of thorium-232 (232Th) with energetic protons, having less than 0.1% of actinium-227 (227Ac) as a byproduct. In order to reduce the 227Ac/225Ac ratio, IRIS will employ the energy range of 40–70 MeV protons irradiated onto the Th target. The target has a structure of 30 mm diameter and a thickness of 3 mm ThO2 with a 0.5 mm-thick aluminum front window, which securely seals the target material. To ensure the stability and safety of thorium targets under high-power beam conditions, a packaging design for the protective Al layer of thorium targets will be adapted and accompanied by detailed mechanical and thermal analyses.