<p>Demand for nickel-based superalloys has increased significantly in the automotive industry because of their great potential to reduce the weight of components and improve efficiency. The present study aims to improve the tribological performance and tool lifespan of the GH4169 alloy through machining, focusing specifically on the potential benefits of using cryogenic cooling. It has better wear and mechanical properties to make this alloy more competitive and viable. Hence, the experiments are conducted under liquid nitrogen (LN₂), carbon dioxide (CO₂), and minimum quantity lubrication (MQL) conditions. The critical tool wear factors have been investigated. The test results proved that cryogenic cooling with the inclusion of MQL helps improve tool life with better tribological characteristics. Furthermore, a hot deformation test was also performed to identify the material’s behavior. The results indicate that flow curves led to smooth regions controlled at low-temperature and high-strain rates. The formation of DRX structures in the processing map is crucial to improving the mechanical properties of these cast components. The Brinell hardness of nickel-based alloys improved after using cooling conditions. Applying the minimum quantity of lubrication cooling conditions exhibits a high hardness of 498 BHN, a 41% increase compared to other conditions.</p>