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<p>The emergence and spread of multidrug-resistant bacteria pose a significant threat to the treatment of lower respiratory tract infections. Our goal was to identify multidrug-resistant bacterial pathogens that cause lower respiratory tract infections, their antibiotic sensitivity patterns, along with extended spectrum β-lactamase, metallo β-lactamase, and methicillin-resistant Staphylococci strains. A total of 724 samples with suspected lower respiratory tract infections were processed using conventional microbiological methods and revealed 219 pathogenic bacteria, of which 137 were multidrug-resistant. Extended spectrum β-lactamase activity was observed more among <i>Klebsiella pneumoniae</i> (34.3%) while metallo β-lactamase among <i>Acinetobacter</i> spp. (27.27%). <i>Staphylococcus aureus</i> that were multidrug-resistant were found to be methicillin-resistant. Our data demonstrate that increasing trend of antimicrobial resistance along with the failure of common antibiotics is creating difficulties in treatment, which thus requires close monitoring and surveillance of those multidrug-resistant pathogens along with the usage of effective antibiotics.</p>

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Multidrug-Resistant Bacterial Etiology Associated with Lower Respiratory Tract Infection in the Patients Attending Shree Birendra Hospital, Chhauni, Kathmandu

  • 期刊论文

  • 发表日期：

    2025年2月7日

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  • Jinu Maharjan,
  • Nabin Narayan Munankarmi,
  • Raina Chaudhary,
  • Sabita Bhatta,
  • Bikash Baral,
  • Reshma Tuladhar

摘要

The emergence and spread of multidrug-resistant bacteria pose a significant threat to the treatment of lower respiratory tract infections. Our goal was to identify multidrug-resistant bacterial pathogens that cause lower respiratory tract infections, their antibiotic sensitivity patterns, along with extended spectrum β-lactamase, metallo β-lactamase, and methicillin-resistant Staphylococci strains. A total of 724 samples with suspected lower respiratory tract infections were processed using conventional microbiological methods and revealed 219 pathogenic bacteria, of which 137 were multidrug-resistant. Extended spectrum β-lactamase activity was observed more among Klebsiella pneumoniae (34.3%) while metallo β-lactamase among Acinetobacter spp. (27.27%). Staphylococcus aureus that were multidrug-resistant were found to be methicillin-resistant. Our data demonstrate that increasing trend of antimicrobial resistance along with the failure of common antibiotics is creating difficulties in treatment, which thus requires close monitoring and surveillance of those multidrug-resistant pathogens along with the usage of effective antibiotics.