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<p>The creation of novel active chemicals using efficient, quick, easy, and environmentally friendly processes is the major problem facing researchers in the biomedical fields as they attempt to combat antibiotic resistance in harmful bacteria. Here, <i>Zingiber officinale</i> aqueous extract was used to generate chitosan nanoparticles by the use of a green synthesis method. The characteristics of green produced Chitosan nanoparticles have been investigated by utilizing X-ray diffraction (XRD), Transmission Electron Microscopy (TEM), scanning electron microscopy-energy dispersive X-ray spectrometry (SEM-EDX), Fourier transform infrared spectroscopy (FT-IR), and UV-Vis spectroscopy. Different sizes and forms of chitosan nanoparticles were created. Testing both Gram-positive &amp;-negative bacteria was done to find out the antibacterial activity of these nanoparticles. Based on their MIC and MBC values, these nanoparticles depicted promising antibacterial activity against <i>S. aureus</i> &amp; <i>E. coli</i> bacteria. When it came to Gram-negative bacteria like <i>E.coli</i>, a greater zone of inhibition had been observed compared to Gram-positive bacteria like <i>S.aureus</i>. This research evaluates the antibacterial characteristics of chitosan nanoparticles and presents a unique production of them using an aqueous extract of <i>Zingiber officinale</i>.</p>

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Green Synthesis of Chitosan Nanoparticles Using Aqueous Extract of Zingiber officinale and Their Application in Antibacterial Activity

  • 期刊论文

  • 发表日期：

    2026年4月17日

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  • Sujit Yadav,
  • Aakriti Prakash,
  • Preeti S. Saxena

摘要

The creation of novel active chemicals using efficient, quick, easy, and environmentally friendly processes is the major problem facing researchers in the biomedical fields as they attempt to combat antibiotic resistance in harmful bacteria. Here, Zingiber officinale aqueous extract was used to generate chitosan nanoparticles by the use of a green synthesis method. The characteristics of green produced Chitosan nanoparticles have been investigated by utilizing X-ray diffraction (XRD), Transmission Electron Microscopy (TEM), scanning electron microscopy-energy dispersive X-ray spectrometry (SEM-EDX), Fourier transform infrared spectroscopy (FT-IR), and UV-Vis spectroscopy. Different sizes and forms of chitosan nanoparticles were created. Testing both Gram-positive &-negative bacteria was done to find out the antibacterial activity of these nanoparticles. Based on their MIC and MBC values, these nanoparticles depicted promising antibacterial activity against S. aureus & E. coli bacteria. When it came to Gram-negative bacteria like E.coli, a greater zone of inhibition had been observed compared to Gram-positive bacteria like S.aureus. This research evaluates the antibacterial characteristics of chitosan nanoparticles and presents a unique production of them using an aqueous extract of Zingiber officinale.