Scholarlink

<p>Obesity, primarily driven by an imbalance between energy intake and expenditure especially due to excessive dietary fat consumption remains challenging to replicate consistently in in vivo models. Achieving a modified high-fat diet while preserving physiological balance remains problematic, hindering reliable obesity models. To address this, a novel Taste Fatigue Monitoring approach via Interval Recording Analysis was employed. Swiss Albino mice (<i>n</i> = 6) were subjected to High Fat Diet (HFD), Normal Diet (ND), and Cafeteria diet (Caff) experimentation across two cages. Using a 13MP camera in time-lapse mode, dietary formulations were meticulously tracked day-wise. Although ND_HFD initially mirrored ND_Caff in terms of contact frequency, it showed a decline in later phases of observation, indicating an earlier onset of satiety or reduced palatability due to the monotony and high fat content of the diet. In contrast, ND_Caff maintained sustained engagement, likely driven by the sensory variety and intermittent reward associated with cafeteria-style feeding. This dynamic approach provides crucial insights into dietary preferences, aiding in designing optimized compositions for sustained intake in obesity research.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Food Contact Point Analysis on in Vivo Induction of Obesity and Associated Diseases: A Novel Methodology for Taste Fatigue Monitoring via Interval Recording Analysis

  • 期刊论文

  • 发表日期：

    2026年6月3日

查看全文
  • Ashok Pattnaik,
  • Tuhin Mukherjee,
  • Anwesha Sahu,
  • Muskan Gupta,
  • Satyajit Mohanty,
  • Ravi Pratap Singh

摘要

Obesity, primarily driven by an imbalance between energy intake and expenditure especially due to excessive dietary fat consumption remains challenging to replicate consistently in in vivo models. Achieving a modified high-fat diet while preserving physiological balance remains problematic, hindering reliable obesity models. To address this, a novel Taste Fatigue Monitoring approach via Interval Recording Analysis was employed. Swiss Albino mice (n = 6) were subjected to High Fat Diet (HFD), Normal Diet (ND), and Cafeteria diet (Caff) experimentation across two cages. Using a 13MP camera in time-lapse mode, dietary formulations were meticulously tracked day-wise. Although ND_HFD initially mirrored ND_Caff in terms of contact frequency, it showed a decline in later phases of observation, indicating an earlier onset of satiety or reduced palatability due to the monotony and high fat content of the diet. In contrast, ND_Caff maintained sustained engagement, likely driven by the sensory variety and intermittent reward associated with cafeteria-style feeding. This dynamic approach provides crucial insights into dietary preferences, aiding in designing optimized compositions for sustained intake in obesity research.