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<p>Aquaculture byproducts offer sustainable inputs for biomedical products. This study reports the development of a functional dermal ointment incorporating Pangas catfish (<i>Pangasianodon hypophthalmus</i>) skin dermal extract (PDE). Lyophilized PDE, confirmed by FTIR to be rich in type I collagen, was formulated into an ointment base at concentrations from 0 to 10% w/w. The inclusion of PDE fundamentally altered the formulation, significantly (<i>p</i> &lt; 0.05) reducing water activity (from 0.93 to 0.90) and pH (from 5.64 to 4.52), thereby enhancing stability. Formulations with ≥ 2.5% PDE showed complete inhibition of fungal growth during one-year storage, whereas control samples developed <i>Candida metapsilosis</i> and <i>Aspergillus flavus</i> contamination. Sensory analysis identified the 5% PDE formulation as optimal in texture and feel. In vitro scratch assays on HaCaT keratinocytes revealed that the 5% PDE ointment drove a superior wound closure rate of 44.91% in 24&#xa0;h—a 2.2-fold increase over the control (20.37%). These results position PDE as a multifunctional, sustainable ingredient that upgrades conventional ointments with enhanced stability, antifungal resistance, and clinically relevant wound healing bioactivity.</p>

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Pangas Catfish Skin Extract Transforms Dermal Ointment with Potent Antifungal and Wound Healing Activity

  • 期刊论文

  • 发表日期：

    2026年4月17日

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  • Siddhnath Kumar,
  • Eshani Sharma,
  • Vikas Kumar

摘要

Aquaculture byproducts offer sustainable inputs for biomedical products. This study reports the development of a functional dermal ointment incorporating Pangas catfish (Pangasianodon hypophthalmus) skin dermal extract (PDE). Lyophilized PDE, confirmed by FTIR to be rich in type I collagen, was formulated into an ointment base at concentrations from 0 to 10% w/w. The inclusion of PDE fundamentally altered the formulation, significantly (p < 0.05) reducing water activity (from 0.93 to 0.90) and pH (from 5.64 to 4.52), thereby enhancing stability. Formulations with ≥ 2.5% PDE showed complete inhibition of fungal growth during one-year storage, whereas control samples developed Candida metapsilosis and Aspergillus flavus contamination. Sensory analysis identified the 5% PDE formulation as optimal in texture and feel. In vitro scratch assays on HaCaT keratinocytes revealed that the 5% PDE ointment drove a superior wound closure rate of 44.91% in 24 h—a 2.2-fold increase over the control (20.37%). These results position PDE as a multifunctional, sustainable ingredient that upgrades conventional ointments with enhanced stability, antifungal resistance, and clinically relevant wound healing bioactivity.