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<p><i>Monoon longifolium</i>, a medicinal plant in the Annonaceae family widely distributed in tropical Asia, is traditionally used for its antimicrobial and anti-inflammatory properties. This study aims to characterize the chemical composition of the leaf essential oil collected from Vietnam, and evaluate its cytotoxic and anti-inflammatory activities. The essential oil, extracted via hydrodistillation, was analyzed using gas chromatography-mass spectrometry (GC-MS), revealing sesquiterpenes as the dominant chemical class, with<i> β</i>-curcumene (15.9%),<i> γ</i>-elemene (12.4%), alloaromadendrene (10.8%), and linalyl isovalerate (6.1%) as the principal compounds. The oil exhibited strong cytotoxicity against SK-LU-1 cancer cells (IC<sub>50</sub>: 7.68 ± 0.27 µg/mL) and significant anti-inflammatory activity in lipopolysaccharide-stimulated RAW 264.7 macrophages (IC<sub>50</sub>: 12.20 ± 1.23 µg/mL), comparable to dexamethasone under the tested conditions. These findings suggest that<i> M. longifolium</i> leaf essential oil is a valuable source of bioactive compounds with potential anticancer and anti-inflammatory applications.</p>

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Essential Oil in Essential Oil from Monoon Longifolium (Sonn.) B. Xue & R.M.K. Saunders: Chemical Profile, Cytotoxic, and Anti-inflammatory Studies

  • 期刊论文

  • 发表日期：

    2026年1月10日

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  • Ty Viet Pham,
  • Ninh The Son

摘要

Monoon longifolium, a medicinal plant in the Annonaceae family widely distributed in tropical Asia, is traditionally used for its antimicrobial and anti-inflammatory properties. This study aims to characterize the chemical composition of the leaf essential oil collected from Vietnam, and evaluate its cytotoxic and anti-inflammatory activities. The essential oil, extracted via hydrodistillation, was analyzed using gas chromatography-mass spectrometry (GC-MS), revealing sesquiterpenes as the dominant chemical class, with β-curcumene (15.9%), γ-elemene (12.4%), alloaromadendrene (10.8%), and linalyl isovalerate (6.1%) as the principal compounds. The oil exhibited strong cytotoxicity against SK-LU-1 cancer cells (IC50: 7.68 ± 0.27 µg/mL) and significant anti-inflammatory activity in lipopolysaccharide-stimulated RAW 264.7 macrophages (IC50: 12.20 ± 1.23 µg/mL), comparable to dexamethasone under the tested conditions. These findings suggest that M. longifolium leaf essential oil is a valuable source of bioactive compounds with potential anticancer and anti-inflammatory applications.