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Purpose <p><i>Streptococcus suis</i> is an important zoonotic pathogen associated with severe disease and mortality. Reduced antimicrobial susceptibility has been increasingly reported. This study aimed to investigate the clinical characteristics, factors associated with mortality, and antimicrobial susceptibility of <i>S. suis</i> infections at a tertiary care hospital in Thailand.</p> Methods <p>A retrospective cohort study was conducted among patients with <i>S. suis</i> infection between 2021 and 2025. Clinical characteristics, treatment outcomes, and antimicrobial susceptibility were collected. Multivariate logistic regression was used to identify factors associated with mortality.</p> Results <p>A total of 87 patients (90 infection episodes) were included. Meningitis (37.8%) and endocarditis (26.7%) were the most common presentations. The in-hospital mortality rate was 11.1%, similar to the 14-day mortality rate (10.0%). Susceptibility testing showed that 34.48% of isolates were susceptible to penicillin, 82.35% to ceftriaxone, and 100% to vancomycin. Septic shock was independently associated with increased mortality (aOR 14.93; 95% CI 1.32–168.26; <i>p</i> = 0.029). Third-generation cephalosporin-based definitive regimens were associated with reduced mortality (aOR 0.10; 95% CI 0.01–0.81; <i>p</i> = 0.032).</p> Conclusion <p>Most deaths occurred early and were associated with disease severity. Reduced susceptibility to penicillin and ceftriaxone was observed. Septic shock predicted mortality, whereas third-generation cephalosporin–based definitive therapy was associated with improved survival. Early recognition and appropriate antimicrobial therapy remain essential.</p>

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Clinical characteristics, antimicrobial susceptibility, and predictors of mortality in Streptococcus suis infection: a retrospective cohort study

  • 期刊论文

  • 发表日期：

    2026年6月15日

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  • Natchaya Pewton,
  • Kunakorn Assawawilaswong,
  • Phusanisa Wasinwasurat,
  • Apisorn Keawruang,
  • Wichai Santimaleeworagun,
  • Patcharapa Boonmee,
  • Puncharat Wongut-Sa,
  • Jatapat Hemapanpairoa

摘要

Purpose

Streptococcus suis is an important zoonotic pathogen associated with severe disease and mortality. Reduced antimicrobial susceptibility has been increasingly reported. This study aimed to investigate the clinical characteristics, factors associated with mortality, and antimicrobial susceptibility of S. suis infections at a tertiary care hospital in Thailand.

Methods

A retrospective cohort study was conducted among patients with S. suis infection between 2021 and 2025. Clinical characteristics, treatment outcomes, and antimicrobial susceptibility were collected. Multivariate logistic regression was used to identify factors associated with mortality.

Results

A total of 87 patients (90 infection episodes) were included. Meningitis (37.8%) and endocarditis (26.7%) were the most common presentations. The in-hospital mortality rate was 11.1%, similar to the 14-day mortality rate (10.0%). Susceptibility testing showed that 34.48% of isolates were susceptible to penicillin, 82.35% to ceftriaxone, and 100% to vancomycin. Septic shock was independently associated with increased mortality (aOR 14.93; 95% CI 1.32–168.26; p = 0.029). Third-generation cephalosporin-based definitive regimens were associated with reduced mortality (aOR 0.10; 95% CI 0.01–0.81; p = 0.032).

Conclusion

Most deaths occurred early and were associated with disease severity. Reduced susceptibility to penicillin and ceftriaxone was observed. Septic shock predicted mortality, whereas third-generation cephalosporin–based definitive therapy was associated with improved survival. Early recognition and appropriate antimicrobial therapy remain essential.