Scholarlink

Purpose <p>Several factors influence the microbiological yield of image-guided biopsy for spondylodiscitis, yet the impact of prior antibiotic exposure remains controversial. Evidence on the effect of antibiotic interruption duration is limited and inconsistent. Although the 2015 Infectious Diseases Society of America guidelines suggest withholding antibiotics before biopsy when feasible, supporting evidence remains insufficient. In this study, we aimed to identify the predictors of microbiological yield, focusing on prior antibiotic exposure and interruption duration.</p> Methods <p>We retrospectively reviewed 53 patients who underwent fluoroscopy- or computed tomography-guided biopsy for spondylodiscitis. Clinical and procedural variables were evaluated for associations with microbiological yield. Among patients receiving antibiotics prior to biopsy, yield was compared according to interruption duration (0–3 vs. ≥ 4&#xa0;days).</p> Results <p>Positive cultures were obtained in 28/53 patients (52.8%). Paravertebral abscess independently predicted positive biopsy yield (odds ratio [OR], 6.80; 95% confidence interval [CI], 1.73–33.62; p = 0.010). Prior antibiotic exposure (60.7% vs. 52%, p = 0.586) and antibiotic interruption (0–3 vs. ≥ 4&#xa0;days: 66.7% vs. 41.7%, p = 0.264) did not significantly affect yield.</p> Conclusion <p>Presence of a paravertebral abscess was associated with higher microbiological yield in image-guided biopsy for spondylodiscitis. Yield was not significantly influenced by prior antibiotic exposure or interruption duration, suggesting that strict antibiotic withholding may not be necessary before biopsy.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Predictors of microbiological yield in image-guided biopsy for spondylodiscitis: impact of prior antibiotic exposure and biopsy timing

  • 期刊论文

  • 发表日期：

    2026年1月31日

查看全文
  • Junya Fuchigami,
  • Shinji Wada,
  • Maki Fuchigami,
  • Yusuke Kobayashi,
  • Hayato Tomita,
  • Kazuki Hashimoto,
  • Shingo Hamaguchi,
  • Shin Matsuoka,
  • Hidefumi Mimura

摘要

Purpose

Several factors influence the microbiological yield of image-guided biopsy for spondylodiscitis, yet the impact of prior antibiotic exposure remains controversial. Evidence on the effect of antibiotic interruption duration is limited and inconsistent. Although the 2015 Infectious Diseases Society of America guidelines suggest withholding antibiotics before biopsy when feasible, supporting evidence remains insufficient. In this study, we aimed to identify the predictors of microbiological yield, focusing on prior antibiotic exposure and interruption duration.

Methods

We retrospectively reviewed 53 patients who underwent fluoroscopy- or computed tomography-guided biopsy for spondylodiscitis. Clinical and procedural variables were evaluated for associations with microbiological yield. Among patients receiving antibiotics prior to biopsy, yield was compared according to interruption duration (0–3 vs. ≥ 4 days).

Results

Positive cultures were obtained in 28/53 patients (52.8%). Paravertebral abscess independently predicted positive biopsy yield (odds ratio [OR], 6.80; 95% confidence interval [CI], 1.73–33.62; p = 0.010). Prior antibiotic exposure (60.7% vs. 52%, p = 0.586) and antibiotic interruption (0–3 vs. ≥ 4 days: 66.7% vs. 41.7%, p = 0.264) did not significantly affect yield.

Conclusion

Presence of a paravertebral abscess was associated with higher microbiological yield in image-guided biopsy for spondylodiscitis. Yield was not significantly influenced by prior antibiotic exposure or interruption duration, suggesting that strict antibiotic withholding may not be necessary before biopsy.