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Objective <p>Vertebral osteomyelitis (VO) is a severe clinical entity associated with high mortality rates, especially within the first year after diagnosis. The aim of this single-center prospective cohort study was to identify and compare predictive factors influencing early and late mortality in patients with conservatively and surgically treated VO. </p> Methods <p>We conducted a single-center prospective cohort study including patients treated for VO between 2008 and 2020 in a tertiary center in Germany to determine early (death within 30&#xa0;days after diagnosis) and late mortality (death between day 31 and 365 after diagnosis). Additionally, multivariable analyses were performed to analyze predictive risk factors for early and late mortality.</p> Results <p>A total of 323 patients were included. 19% died within the first year after diagnosis. Early mortality occurred in 5% and late mortality in 14% of cases. Multivariable analysis revealed chronic kidney disease (CKD) (OR: 13.2, 95% CI 5.7–30.3; p &lt; 0.001) and MSSA (OR: 4.0, 95% CI 1.4–11.1; p = 0.008) as independent risk factors for early mortality, whereas ASA score &gt; 2 (HR: 5.2, 95% CI 2.6–10.6; p &lt; 0.001), age &gt; 70&#xa0;years (HR: 2.4, 95% CI 1.6–3.7; p &lt; 0.001), CKD (HR: 1.9, 95% CI 1.3–3.0; p = 0.003) and bacteremia (HR: 1.8, 95% CI 1.2–2.7; p = 0.002) were identified as independent risk factors for late mortality.</p> Conclusion <p>One out of five VO patients dies within the first year after diagnosis. Risk factors for mortality within the first year include CKD and bacteremia. As a consequence in particular those patients should be closely monitored within the first year after.</p>

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Early and late mortality in vertebral osteomyelitis: who dies within the first year after diagnosis

  • 期刊论文

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  • 发表日期：

    2025年5月9日

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  • Nikolaus Kernich,
  • Arian Abi-Chokami,
  • Norma Jung,
  • Dorothee Jochimsen,
  • Krishnan Sircar,
  • Ada Marie Hoffmann,
  • Stefan Meuser,
  • Peer Eysel,
  • Carolyn Weber,
  • Juan Manuel Vinas-Rios,
  • Ayla Yagdiran,
  • Norma Jung,
  • Ayla Yagdiran,
  • Nikolaus Kernich,
  • Krishnan Sircar,
  • Julia Fischer,
  • Dorothee Jochimsen,
  • Carolyn Weber,
  • Charlotte Meyer-Schwickerath

摘要

Objective

Vertebral osteomyelitis (VO) is a severe clinical entity associated with high mortality rates, especially within the first year after diagnosis. The aim of this single-center prospective cohort study was to identify and compare predictive factors influencing early and late mortality in patients with conservatively and surgically treated VO.

Methods

We conducted a single-center prospective cohort study including patients treated for VO between 2008 and 2020 in a tertiary center in Germany to determine early (death within 30 days after diagnosis) and late mortality (death between day 31 and 365 after diagnosis). Additionally, multivariable analyses were performed to analyze predictive risk factors for early and late mortality.

Results

A total of 323 patients were included. 19% died within the first year after diagnosis. Early mortality occurred in 5% and late mortality in 14% of cases. Multivariable analysis revealed chronic kidney disease (CKD) (OR: 13.2, 95% CI 5.7–30.3; p < 0.001) and MSSA (OR: 4.0, 95% CI 1.4–11.1; p = 0.008) as independent risk factors for early mortality, whereas ASA score > 2 (HR: 5.2, 95% CI 2.6–10.6; p < 0.001), age > 70 years (HR: 2.4, 95% CI 1.6–3.7; p < 0.001), CKD (HR: 1.9, 95% CI 1.3–3.0; p = 0.003) and bacteremia (HR: 1.8, 95% CI 1.2–2.7; p = 0.002) were identified as independent risk factors for late mortality.

Conclusion

One out of five VO patients dies within the first year after diagnosis. Risk factors for mortality within the first year include CKD and bacteremia. As a consequence in particular those patients should be closely monitored within the first year after.