Molecular targeting in the context of insect venom allergy: targets and perspectives
摘要
Background: Molecular technologies have paved the way to improved understanding of allergic diseases in many ways, ranging from molecular allergens to tailor-made tools for analytic, diagnostic, and therapeutic purposes. In particular, the progress in molecular targeting opens a variety of opportunities for improving protection and treatment of allergies and anaphylaxis.
Methods: This review summarizes the state-of-the-art and the feasibility of applying molecular tools for exemplary applications within insect venom allergy and anaphylaxis.
Results: In recent years, novel technologies have been established and applied in the development of antibodies offering advantages compared to current approaches. These antibodies might overcome current limitations and provide novel opportunities for treatment of Hymenoptera venom allergy. Hence, novel targets, molecular architectures, and forms of application of antibodies may provide a benefit for the allergic patient.
Conclusion: Recent approaches give a first glimpse of the future possibilities of targeting approaches in a complex system such as allergic diseases. It has become clear that the simplicity of state-of-the-art antibody technologies will both broaden and deepen the scope of applications in allergology.
Cite this as Ballegaard A-SR, Jensen BK, Aagaard JB, Miehe M, Spillner E. Molecular targeting in the context of insect venom allergy: targets and perspectives. Allergo J Int. 2026;35:8-14