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Background <p>Essential oils (EOs) derived from plants have been utilized for the development of various approaches in biomedicalapplications due to their superior properties. In particular, their antimicrobial, anti-inflammatory, antioxidant, andwound-healing effects, alongside their biocompatibility and biodegradability, have made EOs a significantcomplementary agent in tissue regeneration-focused applications. Initial uses of EOs focused primarily on directapplication and evaluation of their therapeutic efficacy; however, these approaches have been limited by issues suchas volatility, instability, and potential for irritation.</p> Methods <p>This review focuses on current perspectives in tissue engineering strategies, based on the biological functions of EO,such as biocompatibility, antimicrobial, anticancer, and antioxidant properties. Based on this comprehensivebackground of biological functions, current studies addressing nanoparticle systems, smart delivery systems, andwound dressings and coatings have been analyzed to identify existing issues and strategies to tackle thesechallenges.</p> Results <p>In skin tissue engineering applications, innovative strategies such as nanoparticle encapsulation, integration intosmart delivery systems, and the development of wound dressings containing EO have been developed. Theseadvanced approaches offer advantages such as improved EO stability, controlled release, and enhanced efficacy,while also enriching the biofunctionality of the platform. While advanced delivery systems improve the stability ofEOs, long-term stability under physiological and clinical conditions remains challenging. However, compared toconventional methods, these advancements strengthen the potential of EOs to drive tissue repair processes in amore controlled and functional manner.</p> Conclusion <p>The integration of EO-based tissue engineering with nanotechnology offers a promising approach to optimizing thebiological effects of these systems and enhancing the success of their application. Although challenges such assafety, biomaterial interactions, and scalability persist, recent advancements are rapidly overcoming theseobstacles. EO-based strategies hold significant potential for overcoming current limitations and advancing the field,particularly in skin tissue engineering.</p>

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Essential Oils in Skin Tissue Engineering: Opportunities, Integration, and Overcoming Challenges

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年7月17日

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  • Elif Emekdar,
  • Selcen Ari Yuka,
  • Azime Erarslan

摘要

Background

Essential oils (EOs) derived from plants have been utilized for the development of various approaches in biomedicalapplications due to their superior properties. In particular, their antimicrobial, anti-inflammatory, antioxidant, andwound-healing effects, alongside their biocompatibility and biodegradability, have made EOs a significantcomplementary agent in tissue regeneration-focused applications. Initial uses of EOs focused primarily on directapplication and evaluation of their therapeutic efficacy; however, these approaches have been limited by issues suchas volatility, instability, and potential for irritation.

Methods

This review focuses on current perspectives in tissue engineering strategies, based on the biological functions of EO,such as biocompatibility, antimicrobial, anticancer, and antioxidant properties. Based on this comprehensivebackground of biological functions, current studies addressing nanoparticle systems, smart delivery systems, andwound dressings and coatings have been analyzed to identify existing issues and strategies to tackle thesechallenges.

Results

In skin tissue engineering applications, innovative strategies such as nanoparticle encapsulation, integration intosmart delivery systems, and the development of wound dressings containing EO have been developed. Theseadvanced approaches offer advantages such as improved EO stability, controlled release, and enhanced efficacy,while also enriching the biofunctionality of the platform. While advanced delivery systems improve the stability ofEOs, long-term stability under physiological and clinical conditions remains challenging. However, compared toconventional methods, these advancements strengthen the potential of EOs to drive tissue repair processes in amore controlled and functional manner.

Conclusion

The integration of EO-based tissue engineering with nanotechnology offers a promising approach to optimizing thebiological effects of these systems and enhancing the success of their application. Although challenges such assafety, biomaterial interactions, and scalability persist, recent advancements are rapidly overcoming theseobstacles. EO-based strategies hold significant potential for overcoming current limitations and advancing the field,particularly in skin tissue engineering.