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<Emphasis Type="BoldItalic">BACKGROUND</Emphasis>: <p>Achieving stable and functional integration of synthetic implants with host tissue remains a key challenge in tissue engineering. Medpor®, a porous high-density polyethylene (HDPE) implant widely used in craniofacial reconstruction, provides excellent mechanical strength but lacks bioactivity, limiting early cell adhesion, vascularization, and extracellular matrix (ECM) deposition.</p> <Emphasis Type="BoldItalic">METHODS</Emphasis>: <p>To enhance Medpor® biointegration, we employed a multi-faceted modification strategy combining plasma treatment with biologically active components. Treated implants were coated with collagen and fibrin hydrogels and further supplemented with a platelet-derived Purified Exosome Product (PEP). Modified and control implants were evaluated in a subcutaneous mouse model to assess host tissue response, vascularization, and implant integration.</p> <Emphasis Type="BoldItalic">RESULTS</Emphasis>: <p>Tissue ingrowth was observed in the pores of all Medpor® implants. Plasma treatment significantly increased the surface hydrophilicity of Medpor®, promoting host cell adhesion and tissue infiltration. Implants modified with both hydrogels and PEP exhibited enhanced ECM deposition, greater vascular density, and improved tissue integration compared to untreated Medpor®. The combination of physicochemical surface treatment and biochemical cues led to a synergistic effect, supporting tissue ingrowth and angiogenesis under a controlled host immune response.</p> <Emphasis Type="BoldItalic">CONCLUSION</Emphasis>: <p>This study demonstrates that integrating plasma surface modification with bioactive hydrogels and PEP can effectively enhance the biointegration of Medpor® implants <i>in vivo</i>. The combined approach significantly enhances implant vascularization and ECM development, offering a promising translational strategy for improving synthetic implant performance in regenerative and reconstructive biomaterial applications.</p>

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Combining Surface Modification and Bioactive Cues to Enhance Medpor® Implant Integration In Vivo

  • 期刊论文

  • 发表日期：

    2026年1月12日

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  • Dina Gadalla,
  • Maeve M. Kennedy,
  • Jamie E. Ganem,
  • Sriya Yeleswarapu,
  • Amanda M. Richards,
  • Rachel M. Wells,
  • David G. Lott

摘要

BACKGROUND:

Achieving stable and functional integration of synthetic implants with host tissue remains a key challenge in tissue engineering. Medpor®, a porous high-density polyethylene (HDPE) implant widely used in craniofacial reconstruction, provides excellent mechanical strength but lacks bioactivity, limiting early cell adhesion, vascularization, and extracellular matrix (ECM) deposition.

METHODS:

To enhance Medpor® biointegration, we employed a multi-faceted modification strategy combining plasma treatment with biologically active components. Treated implants were coated with collagen and fibrin hydrogels and further supplemented with a platelet-derived Purified Exosome Product (PEP). Modified and control implants were evaluated in a subcutaneous mouse model to assess host tissue response, vascularization, and implant integration.

RESULTS:

Tissue ingrowth was observed in the pores of all Medpor® implants. Plasma treatment significantly increased the surface hydrophilicity of Medpor®, promoting host cell adhesion and tissue infiltration. Implants modified with both hydrogels and PEP exhibited enhanced ECM deposition, greater vascular density, and improved tissue integration compared to untreated Medpor®. The combination of physicochemical surface treatment and biochemical cues led to a synergistic effect, supporting tissue ingrowth and angiogenesis under a controlled host immune response.

CONCLUSION:

This study demonstrates that integrating plasma surface modification with bioactive hydrogels and PEP can effectively enhance the biointegration of Medpor® implants in vivo. The combined approach significantly enhances implant vascularization and ECM development, offering a promising translational strategy for improving synthetic implant performance in regenerative and reconstructive biomaterial applications.