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BACKGROUND: <p>Curcumin, a well-known wound healing agent, faces clinical limitations due to its poor water solubility, rapid degradation, and short plasma half-life. To address these challenges, we developed a self-assembling peptide incorporating an antioxidant sequence (YGDEY), which is capable of not only delivering curcumin but also exhibiting additional bioactivity to enhance wound healing.</p> METHODS: <p>An antioxidant nanocarrier was developed via peptide self-assembly. To design an amphiphilic peptide for the nanocarrier assembly, antioxidant peptide sequence (YGDEY) as the hydrophilic segment and the hydrophobic block (WLWL) were incorporated to single peptide molecule. The peptide's self-assembly behavior and curcumin encapsulation were initially analyzed. Subsequent evaluations included cytocompatibility, cellular uptake, and antioxidant activity.</p> RESULTS: <p>Driven by strong interactions among their hydrophobic blocks (WLWL), the peptides formed well-defined nanostructures exhibiting high thermal stability. Furthermore, the encapsulation of curcumin within the micelle significantly improved its cellular penetration efficiency. When applied to fibroblast cells, the peptide-curcumin nanocomplexes exhibited synergistically enhanced antioxidant activity, which notably outperformed free curcumin and free peptide in scavenging reactive oxygen species.</p> CONCLUSION: <p>These findings highlight the potential of the designed peptide-based nanocarrier to overcome intrinsic limitations of curcumin and enhance its therapeutic efficacy, providing a promising strategy for advanced wound healing applications.</p>

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Antioxidant Peptide-Based Nanocarriers for Delivering Wound Healing Agents

  • 期刊论文

  • 发表日期：

    2025年2月10日

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  • Inseo Lee,
  • Woo Hyun Kwon,
  • Joo-young Kim,
  • Ha Kyeong Kim,
  • Ji-eun Kim,
  • Yong-beom Lim,
  • Woo-jin Jeong,
  • Jun Shik Choi

摘要

BACKGROUND:

Curcumin, a well-known wound healing agent, faces clinical limitations due to its poor water solubility, rapid degradation, and short plasma half-life. To address these challenges, we developed a self-assembling peptide incorporating an antioxidant sequence (YGDEY), which is capable of not only delivering curcumin but also exhibiting additional bioactivity to enhance wound healing.

METHODS:

An antioxidant nanocarrier was developed via peptide self-assembly. To design an amphiphilic peptide for the nanocarrier assembly, antioxidant peptide sequence (YGDEY) as the hydrophilic segment and the hydrophobic block (WLWL) were incorporated to single peptide molecule. The peptide's self-assembly behavior and curcumin encapsulation were initially analyzed. Subsequent evaluations included cytocompatibility, cellular uptake, and antioxidant activity.

RESULTS:

Driven by strong interactions among their hydrophobic blocks (WLWL), the peptides formed well-defined nanostructures exhibiting high thermal stability. Furthermore, the encapsulation of curcumin within the micelle significantly improved its cellular penetration efficiency. When applied to fibroblast cells, the peptide-curcumin nanocomplexes exhibited synergistically enhanced antioxidant activity, which notably outperformed free curcumin and free peptide in scavenging reactive oxygen species.

CONCLUSION:

These findings highlight the potential of the designed peptide-based nanocarrier to overcome intrinsic limitations of curcumin and enhance its therapeutic efficacy, providing a promising strategy for advanced wound healing applications.