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<p>Nuclear magnetic resonance (NMR) is of vital importance for chemical structure characterization. Over the last decade, low-field NMR spectroscopy (LF-NMR) has forced noticeable growth in chemical analysis and quality control processes. Benchtop (also known as table-top or compact) NMR instruments are small and compact, offering the benefit of being locatable on a table or in a fume-hood. Most importantly, as they employ the spectroscopic-grade permanent magnets processing at room temperature, the dependence on non-renewable natural resources (helium and nitrogen) for cryogenic cooling is avoided. Although the quality of LF-NMR never reaches the level of data provided by high-field NMR (HF-NMR) instruments, the field is indeed trending and deserves attention when taking into account the advantages of the daily use possibility of working in an&#xa0;environmentally benign and cost and time saving mode. Herein, we highlight LF-NMR spectroscopy as profitable analytical tool for structural determination in an organic laboratory immediately upon synthesis. The accurate characterization by <sup>1</sup>H LF-NMR is presented on a&#xa0;set of compounds, <b>1</b>–<b>6,</b> representing the&#xa0;products of an undergraduate laboratory course. The comparative proton LF-/ HF-NMR is presented for pharmaceuticals <b>7</b>, <b>8</b> synthesized de-novo during the advanced laboratory course. Finally, the sole LF-NMR has been successfully applied for <sup>1</sup>H and 2D (<sup>1</sup>H-<sup>1</sup>H) COSY NMR experiments for&#xa0;structural characterization of azomethine <b>7</b> representing a&#xa0;compound of our research aims.</p>

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Low-field nuclear magnetic resonance as an environmentally benign and energy saving analytical tool in organic laboratories

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  • 发表日期：

    2025年1月6日

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  • M. Gašparová,
  • Z. Tokárová

摘要

Nuclear magnetic resonance (NMR) is of vital importance for chemical structure characterization. Over the last decade, low-field NMR spectroscopy (LF-NMR) has forced noticeable growth in chemical analysis and quality control processes. Benchtop (also known as table-top or compact) NMR instruments are small and compact, offering the benefit of being locatable on a table or in a fume-hood. Most importantly, as they employ the spectroscopic-grade permanent magnets processing at room temperature, the dependence on non-renewable natural resources (helium and nitrogen) for cryogenic cooling is avoided. Although the quality of LF-NMR never reaches the level of data provided by high-field NMR (HF-NMR) instruments, the field is indeed trending and deserves attention when taking into account the advantages of the daily use possibility of working in an environmentally benign and cost and time saving mode. Herein, we highlight LF-NMR spectroscopy as profitable analytical tool for structural determination in an organic laboratory immediately upon synthesis. The accurate characterization by 1H LF-NMR is presented on a set of compounds, 1–6, representing the products of an undergraduate laboratory course. The comparative proton LF-/ HF-NMR is presented for pharmaceuticals 7, 8 synthesized de-novo during the advanced laboratory course. Finally, the sole LF-NMR has been successfully applied for 1H and 2D (1H-1H) COSY NMR experiments for structural characterization of azomethine 7 representing a compound of our research aims.