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<p>The persistence of living systems depends on their capacity to sense, distribute, and resolve stress. Across evolution, this pressure shaped increasingly integrated architectures that align local perception with collective regulation, enabling the emergence of multicellular form. Here, I argue that chronic, unresolvable stress exposes a fundamental vulnerability of these architectures and drives the breakdown of tissue-level coordination. Synthesizing perspectives from evolutionary and developmental biology, cancer biology, and trauma psychology, I propose that tumorigenesis represents a <i>morphogenetic trauma response</i>: a stress-induced dissociation in which cells lose access to shared regulatory memory and enact self-reinforcing, anatomically intrusive behaviors. This claim is advanced as a structural analogy rather than a claim of psychological causation, situating trauma as a general biological phenomenon that can manifest across distinct substrates and scales. This view carries therapeutic implications, suggesting a reintegrative approach that seeks to return cancer cells to the homeostatic control of the surrounding tissue.</p>

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Tumorigenesis as a Trauma Response: The Fragmentation of Morphogenetic Memory Drives Neoplastic Dissociation

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  • 发表日期：

    2026年4月29日

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  • Jordan Strasser

摘要

The persistence of living systems depends on their capacity to sense, distribute, and resolve stress. Across evolution, this pressure shaped increasingly integrated architectures that align local perception with collective regulation, enabling the emergence of multicellular form. Here, I argue that chronic, unresolvable stress exposes a fundamental vulnerability of these architectures and drives the breakdown of tissue-level coordination. Synthesizing perspectives from evolutionary and developmental biology, cancer biology, and trauma psychology, I propose that tumorigenesis represents a morphogenetic trauma response: a stress-induced dissociation in which cells lose access to shared regulatory memory and enact self-reinforcing, anatomically intrusive behaviors. This claim is advanced as a structural analogy rather than a claim of psychological causation, situating trauma as a general biological phenomenon that can manifest across distinct substrates and scales. This view carries therapeutic implications, suggesting a reintegrative approach that seeks to return cancer cells to the homeostatic control of the surrounding tissue.