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<p>Thiazoles and their derivatives hold significant importance in the field of medicinal chemistry due to their promising potential as pharmaceutical agents. Conventional synthetic methods of thiazoles often rely on hazardous reagents and generate substantial chemical waste in addition to high cost, low yields and long reaction time. Consequently, the development of benign and sustainable methodologies for thiazole construction has become a primary objective within the framework of Green Chemistry. This review provides a comprehensive overview of sustainable synthetic approaches for thiazole derivatives in the period 2022–2026. We highlight key advancements such as microwave-assisted synthesis, ultrasound irradiation, solvent-free grinding techniques, multicomponent reactions, and the use of sustainable catalytic systems such as ionic liquids, deep eutectic solvents, biocatalysts, and nanocatalysts. These methodologies offer significant advantages including high efficiency, short reaction times, excellent yields, and reduced environmental impact compared to conventional synthetic routes.</p>

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Recent trends in the green synthesis and reactions of thiazole-based heterocycles

  • 期刊论文

  • 发表日期：

    2026年7月11日

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  • Anhar Abdel-Aziem

摘要

Thiazoles and their derivatives hold significant importance in the field of medicinal chemistry due to their promising potential as pharmaceutical agents. Conventional synthetic methods of thiazoles often rely on hazardous reagents and generate substantial chemical waste in addition to high cost, low yields and long reaction time. Consequently, the development of benign and sustainable methodologies for thiazole construction has become a primary objective within the framework of Green Chemistry. This review provides a comprehensive overview of sustainable synthetic approaches for thiazole derivatives in the period 2022–2026. We highlight key advancements such as microwave-assisted synthesis, ultrasound irradiation, solvent-free grinding techniques, multicomponent reactions, and the use of sustainable catalytic systems such as ionic liquids, deep eutectic solvents, biocatalysts, and nanocatalysts. These methodologies offer significant advantages including high efficiency, short reaction times, excellent yields, and reduced environmental impact compared to conventional synthetic routes.