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<p>A multipurpose, bioactive PLA-based film containing quercetin obtained from plants was developed in response to the growing number of chronic, biofilm-infected wounds and the shortcomings of passive dressings. The study has effectively synthesized and developed a new, biocomposite film as a high-ranking wound dressing using <i>Crateva religiosa</i>-extracted Quercetin in polylactic acid (PLA). The molecular interactions through hydrogen bonding between the carbonyls of PLA and phenolic hydroxyls of Quercetin were confirmed by FTIR spectroscopy. The fabricated biocomposite films had strong dose-dependent biological actions. Existing 2 wt% Quercetin film (PLA-Q2) exhibited considerable antimicrobial effect with 10.8 ± 0.6&#xa0;mm and 9.5 ± 0.4&#xa0;mm of inhibition zone against <i>S. aureus</i> and <i>E. coli</i>, respectively. Moreover, the films demonstrated a high level of antioxidant activity (71.64% DPPH scavenging at 1000&#xa0;µg/mL of PLA-Q3). The high and selective cytotoxicity was observed on MCF-7 breast cancer cells, reducing cell survival to 8.88% in 3% quercetin added. The PLA-Q2 film exhibited balanced mechanical properties, including good strength (50.2&#xa0;MPa) and improved flexibility (9.6%), which makes it suitable for wound dressing applications. The Quercetin (2%wt.) formulation (PLA-Q2) was determined to be the best option for wound dressing applications based on its combination of mechanical, antibacterial, and antioxidant efficacy. This work presents a novel bioactive platform with improved biodegradability and multi-targeted action against infection, oxidative stress, inflammation, and potentially cancer recurrence.</p>

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Sustainable PLA/quercetin bioactive films reinforced with Crateva religiosa extract: mechanical, antioxidant, and antimicrobial performance

  • 期刊论文

  • 发表日期：

    2026年5月30日

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  • Sebin Fernandez,
  • L. Cathrine,
  • F. Virginia

摘要

A multipurpose, bioactive PLA-based film containing quercetin obtained from plants was developed in response to the growing number of chronic, biofilm-infected wounds and the shortcomings of passive dressings. The study has effectively synthesized and developed a new, biocomposite film as a high-ranking wound dressing using Crateva religiosa-extracted Quercetin in polylactic acid (PLA). The molecular interactions through hydrogen bonding between the carbonyls of PLA and phenolic hydroxyls of Quercetin were confirmed by FTIR spectroscopy. The fabricated biocomposite films had strong dose-dependent biological actions. Existing 2 wt% Quercetin film (PLA-Q2) exhibited considerable antimicrobial effect with 10.8 ± 0.6 mm and 9.5 ± 0.4 mm of inhibition zone against S. aureus and E. coli, respectively. Moreover, the films demonstrated a high level of antioxidant activity (71.64% DPPH scavenging at 1000 µg/mL of PLA-Q3). The high and selective cytotoxicity was observed on MCF-7 breast cancer cells, reducing cell survival to 8.88% in 3% quercetin added. The PLA-Q2 film exhibited balanced mechanical properties, including good strength (50.2 MPa) and improved flexibility (9.6%), which makes it suitable for wound dressing applications. The Quercetin (2%wt.) formulation (PLA-Q2) was determined to be the best option for wound dressing applications based on its combination of mechanical, antibacterial, and antioxidant efficacy. This work presents a novel bioactive platform with improved biodegradability and multi-targeted action against infection, oxidative stress, inflammation, and potentially cancer recurrence.