<p>Drug that interact with various targets of either of single disease or numerous disease pathways are referred to as polypharmacology. This idea has been highly valued in the context of complicated disorders; including cancer, anti-Alzheimer, antiepileptic and anti-infective. Research on polypharmacological drug discovery is started by combining several substances that are accessible through public databases. Patient having impaired immune system suffered from complicated disease. Drug formulations have multiple compositions which may cause resistance problem and adverse effect because of unintentional drug-target intentions. Polypharmacology is still a new approach to aim for less harmful and more productive outcomes. Phthalic anhydride scaffold has emerged as a crucial novel medication to combat infectious disease including Alzheimer, Epilepsy, cancer and other disorder of life style. The present study is an attempt to explore the polypharmacological effects of phthalic anhydride compounds on to combat microbial infection, inflammation, Alzheimer, Epilepsy and cancer. Also provide systematically compile and present all available information in a manner that will be beneficial for future research.</p>