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<p>The methodical conceptualization and fabrication of novel compounds demonstrating both effectiveness and safety profiles has consistently posed a significant challenge in pharmaceutical development. Recent investigations have revealed that oxadiazole serves as the biologically active component present in an array of chemical entities. Derivatives of oxadiazole demonstrate a spectrum of biological activities, including antibacterial, anti-inflammatory, antitubercular, antifungal, antidiabetic, and anticancer properties. These compounds are known to exist in four regioisomeric forms, specifically 1,3,4-oxadiazole, 1,2,3-oxadiazole, 1,2,4-oxadiazole, and 1,2,5-oxadiazole. The extensive and potent biological activities of 1,3,4-oxadiazole and its derivatives have become important pharmacological scaffolds particularly in the therapeutic management of cancer. Many aromatic, tri-, di and heterocyclic substituted derivatives of 1,3,4-oxadiazole have been documented to exhibit substantial anticancer efficacy. The goal of this review article is to present a thorough and organized summary of compounds that include oxadiazole derivatives. Additionally, The synthetic processes that result in the production of oxadiazoles are investigated alongside their biological relevance. </p> Graphical abstract <p></p>

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Oxadiazole derivatives as potent biological active agent: a review

  • 期刊论文

  • 发表日期：

    2026年1月5日

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  • Muqadas Bibi,
  • Freeha Hafeez,
  • Muhammad Suleman

摘要

The methodical conceptualization and fabrication of novel compounds demonstrating both effectiveness and safety profiles has consistently posed a significant challenge in pharmaceutical development. Recent investigations have revealed that oxadiazole serves as the biologically active component present in an array of chemical entities. Derivatives of oxadiazole demonstrate a spectrum of biological activities, including antibacterial, anti-inflammatory, antitubercular, antifungal, antidiabetic, and anticancer properties. These compounds are known to exist in four regioisomeric forms, specifically 1,3,4-oxadiazole, 1,2,3-oxadiazole, 1,2,4-oxadiazole, and 1,2,5-oxadiazole. The extensive and potent biological activities of 1,3,4-oxadiazole and its derivatives have become important pharmacological scaffolds particularly in the therapeutic management of cancer. Many aromatic, tri-, di and heterocyclic substituted derivatives of 1,3,4-oxadiazole have been documented to exhibit substantial anticancer efficacy. The goal of this review article is to present a thorough and organized summary of compounds that include oxadiazole derivatives. Additionally, The synthetic processes that result in the production of oxadiazoles are investigated alongside their biological relevance.

Graphical abstract