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<p>Tumor-to-tumor metastasis (TTM) is a rare clinicopathological phenomenon in which a malignant tumor metastasizes to another distinct neoplasm. Although renal cell carcinoma (RCC) is a frequent recipient tumor, metastasis from breast carcinoma to RCC is extremely rare. A 64-year-old woman with long-standing hormone receptor–positive breast carcinoma presented with a 23-mm enhancing right renal mass. Robot-assisted partial nephrectomy revealed clear cell RCC with intratumoral nests of metastatic breast carcinoma. Immunohistochemistry revealed a reciprocal staining profile: RCC cells were positive for PAX8 and CA9, whereas metastatic breast carcinoma cells expressed CK7 and GATA3 with weak ER positivity. Clear cell RCC may serve as a recipient tumor for breast carcinoma metastasis, emphasizing that TTM should be considered in the differential diagnosis of renal masses in patients with a history of breast carcinoma, even when imaging findings are consistent with conventional RCC.</p>

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Tumor-to-tumor metastasis of breast carcinoma to clear cell renal cell carcinoma: a rare case with a review of the literature

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年7月28日

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  • Nobuyuki Nakajima,
  • Hiroshi Kajiwara,
  • Kenta Okutsu,
  • Toshiki Sakemura,
  • Haruka Ikoma,
  • Tatsuya Otaki,
  • Soichiro Yuzuriha,
  • Takato Uchida,
  • Tatsuya Umemoto,
  • Yoshiaki Kawamura,
  • Yohei Masugi,
  • Sunao Shoji

摘要

Tumor-to-tumor metastasis (TTM) is a rare clinicopathological phenomenon in which a malignant tumor metastasizes to another distinct neoplasm. Although renal cell carcinoma (RCC) is a frequent recipient tumor, metastasis from breast carcinoma to RCC is extremely rare. A 64-year-old woman with long-standing hormone receptor–positive breast carcinoma presented with a 23-mm enhancing right renal mass. Robot-assisted partial nephrectomy revealed clear cell RCC with intratumoral nests of metastatic breast carcinoma. Immunohistochemistry revealed a reciprocal staining profile: RCC cells were positive for PAX8 and CA9, whereas metastatic breast carcinoma cells expressed CK7 and GATA3 with weak ER positivity. Clear cell RCC may serve as a recipient tumor for breast carcinoma metastasis, emphasizing that TTM should be considered in the differential diagnosis of renal masses in patients with a history of breast carcinoma, even when imaging findings are consistent with conventional RCC.