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<p>A 45-year-old man with a low titer of hepatitis B virus (HBV) was diagnosed with nephrotic syndrome. A subsequent test for human immunodeficiency virus (HIV) was positive. Kidney biopsy revealed some signs of collapsing variant of focal segmental glomerulosclerosis (FSGS), but the predominant finding was a cellular variant of FSGS. Two years after receiving tenofovir, urine protein became negative, and the patient was finally diagnosed with HIV-associated nephropathy. Collapsing variant of FSGS is considered typical of HIV-related nephropathy, but the cellular variant of FSGS in this patient represents another type. The cause of many FSGSs is often never identified, making cause-based treatment difficult. This case demonstrates that identification of the cause of FSGS can lead to treatment of FSGS.</p>

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Human immunodeficiency virus-associated nephropathy mainly due to cellular variant of focal segmental glomerulosclerosis

  • 期刊论文

  • 发表日期：

    2025年3月17日

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  • Hikaru Tanimizu,
  • Naoki Sawa,
  • Akinari Sekine,
  • Yuki Oba,
  • Masayuki Yamanouchi,
  • Eiko Hasegawa,
  • Tatsuya Suwabe,
  • Junichi Hoshino,
  • Keiichi Kinowaki,
  • Kei Kono,
  • Kenichi Ohashi,
  • Yukiko Kanetsuna,
  • Kazuho Honda,
  • Kensuke Joh,
  • Yutaka Yamaguchi,
  • Takehiko Wada,
  • Yoshifumi Ubara

摘要

A 45-year-old man with a low titer of hepatitis B virus (HBV) was diagnosed with nephrotic syndrome. A subsequent test for human immunodeficiency virus (HIV) was positive. Kidney biopsy revealed some signs of collapsing variant of focal segmental glomerulosclerosis (FSGS), but the predominant finding was a cellular variant of FSGS. Two years after receiving tenofovir, urine protein became negative, and the patient was finally diagnosed with HIV-associated nephropathy. Collapsing variant of FSGS is considered typical of HIV-related nephropathy, but the cellular variant of FSGS in this patient represents another type. The cause of many FSGSs is often never identified, making cause-based treatment difficult. This case demonstrates that identification of the cause of FSGS can lead to treatment of FSGS.