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<p>Wound healing represents a highly coordinated biological process in which damaged tissue undergoes repair and regeneration. In the present study, <i>Hibiscus rosa-sinensis</i>-pectin hydrogel films (HRS-PHF) were evaluated for their wound healing potential using a partial-thickness burn model in male Sprague Dawley rats. Three concentrations of HRS-PHF and a pectin-only hydrogel film (PHF) were prepared through solvent evaporation and characterized in detail. The films were examined for their physicochemical and structural properties using scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), and X-ray diffraction (XRD), along with measurements of thickness, pH, moisture content, contact angle, and swelling ratio. Antimicrobial activity was tested against <i>Pseudomonas aeruginosa</i> and <i>Staphylococcus aureus</i>, while anti-inflammatory effects were assessed using the bovine serum albumin (BSA) protein denaturation assay. Wound progression was evaluated macroscopically on days 0, 2, 7, 14, and 21, followed by histological confirmation. All HRS-PHF-treated groups exhibited accelerated wound closure compared to PHF and control groups, accompanied by enhanced re-epithelialization and greater collagen deposition by day 14 (ANOVA; <i>p</i> &lt; 0.05). Improved hydrophilicity was observed in HRS-PHF-1, and XRD results confirmed the films’ amorphous characteristics. HRS-PHF-2 and HRS-PHF-3 showed notable antibacterial activity, with HRS-PHF-3 demonstrating anti-inflammatory activity comparable to diclofenac sodium (ANOVA; <i>p</i> &gt; 0.05). Collectively, these findings indicate that HRS-PHF possesses desirable multifunctional properties suitable for advanced wound dressing applications.</p> Graphical abstract <p></p>

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Preparation and properties of Hibiscus rosa sinensis-pectin hydrogel film for enhanced partial-thickness wound healing

  • 期刊论文

  • 发表日期：

    2026年5月2日

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  • Aziz Nur Karimah,
  • Wan Chik Mazzura,
  • Tin Wui Wong,
  • Wan Engah Wan Rozita,
  • Anuar Nor Khaizan

摘要

Wound healing represents a highly coordinated biological process in which damaged tissue undergoes repair and regeneration. In the present study, Hibiscus rosa-sinensis-pectin hydrogel films (HRS-PHF) were evaluated for their wound healing potential using a partial-thickness burn model in male Sprague Dawley rats. Three concentrations of HRS-PHF and a pectin-only hydrogel film (PHF) were prepared through solvent evaporation and characterized in detail. The films were examined for their physicochemical and structural properties using scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), and X-ray diffraction (XRD), along with measurements of thickness, pH, moisture content, contact angle, and swelling ratio. Antimicrobial activity was tested against Pseudomonas aeruginosa and Staphylococcus aureus, while anti-inflammatory effects were assessed using the bovine serum albumin (BSA) protein denaturation assay. Wound progression was evaluated macroscopically on days 0, 2, 7, 14, and 21, followed by histological confirmation. All HRS-PHF-treated groups exhibited accelerated wound closure compared to PHF and control groups, accompanied by enhanced re-epithelialization and greater collagen deposition by day 14 (ANOVA; p < 0.05). Improved hydrophilicity was observed in HRS-PHF-1, and XRD results confirmed the films’ amorphous characteristics. HRS-PHF-2 and HRS-PHF-3 showed notable antibacterial activity, with HRS-PHF-3 demonstrating anti-inflammatory activity comparable to diclofenac sodium (ANOVA; p > 0.05). Collectively, these findings indicate that HRS-PHF possesses desirable multifunctional properties suitable for advanced wound dressing applications.

Graphical abstract