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<p>Penile cancer is a rare malignancy, with squamous cell carcinoma (SCC) being the predominant histological type. Mucoepidermoid carcinoma (MEC) of the penis is an extremely rare variant, making its clinicopathological features and prognosis poorly understood. We report the case of an 87-year-old man who presented with penile swelling and an ulcerative lesion. An initial biopsy initially suggested SCC. However, histopathological analysis of the total penectomy specimen revealed features consistent with MEC, characterized by a mixture of mucin-producing squamoid and intermediate cells. The tumor appeared to originate from the transitional zone between the prepuce and glans. Importantly, molecular analysis did not detect the <i>CRTC1/CRTC3</i>-<i>MAML2</i> fusion gene, a finding potentially associated with a poorer prognosis. This case highlights a rare and challenging diagnosis of penile cancer. The absence of the common MEC-associated fusion gene may indicate a more aggressive clinical course. Further accumulation of cases with detailed molecular characterization is crucial to clarify the pathogenesis, behavior, and optimal management strategies for this rare entity.</p>

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Penile mucoepidermoid carcinoma lacking CRTC1/CRTC3–MAML2 fusion: a case report and review of the literature

  • 期刊论文

  • 发表日期：

    2025年11月21日

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  • Satoshi Ohno,
  • Shinro Hata,
  • Kazuhiro Kawamura,
  • Yuzo Oyama,
  • Masahiro Todaka,
  • Satoki Abe,
  • Shuntaro Suzuki,
  • Hiroyuki Fujinami,
  • Tsutomu Daa,
  • Toshitaka Shin

摘要

Penile cancer is a rare malignancy, with squamous cell carcinoma (SCC) being the predominant histological type. Mucoepidermoid carcinoma (MEC) of the penis is an extremely rare variant, making its clinicopathological features and prognosis poorly understood. We report the case of an 87-year-old man who presented with penile swelling and an ulcerative lesion. An initial biopsy initially suggested SCC. However, histopathological analysis of the total penectomy specimen revealed features consistent with MEC, characterized by a mixture of mucin-producing squamoid and intermediate cells. The tumor appeared to originate from the transitional zone between the prepuce and glans. Importantly, molecular analysis did not detect the CRTC1/CRTC3-MAML2 fusion gene, a finding potentially associated with a poorer prognosis. This case highlights a rare and challenging diagnosis of penile cancer. The absence of the common MEC-associated fusion gene may indicate a more aggressive clinical course. Further accumulation of cases with detailed molecular characterization is crucial to clarify the pathogenesis, behavior, and optimal management strategies for this rare entity.