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<p>A 57-year-old woman with newly diagnosed breast cancer presented with diffuse skeletal pain, predominantly in the spine. Imaging, including whole-body bone scintigraphy, revealed multiple bony lesions in the skull, spine, ribs, pelvis, and femora, indicating widespread bone metastasis. Additionally, diffuse calcification was observed in the lungs, heart, and stomach, consistent with metastatic calcification. However, CT scans only showed diffuse lytic-sclerotic lesions in the skeleton without evidence of visceral calcification. The laboratory tests revealed elevated serum calcium, phosphorus, and creatinine levels, with normal parathyroid hormone (PTH) levels. This case underscores the critical role of bone scintigraphy in the early diagnosis and monitoring of metastatic bone disease in breast cancer patients. It highlights the superiority of bone scintigraphy over CT scans in detecting early-stage visceral calcification, emphasizing the importance of early recognition and management of metastatic calcification and hypercalcemia in cancer patients.</p>

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Metastatic calcification due to diffuse lytic skeletal metastases, a rare presentation of breast cancer unveiled by bone scintigraphy and CT scan

  • 期刊论文

  • 发表日期：

    2026年1月3日

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  • Reihaneh Mohammadhosseini,
  • Leila Karimi,
  • Parva Javanshayani,
  • Hadi Milani,
  • Mohammadali Ghodsirad

摘要

A 57-year-old woman with newly diagnosed breast cancer presented with diffuse skeletal pain, predominantly in the spine. Imaging, including whole-body bone scintigraphy, revealed multiple bony lesions in the skull, spine, ribs, pelvis, and femora, indicating widespread bone metastasis. Additionally, diffuse calcification was observed in the lungs, heart, and stomach, consistent with metastatic calcification. However, CT scans only showed diffuse lytic-sclerotic lesions in the skeleton without evidence of visceral calcification. The laboratory tests revealed elevated serum calcium, phosphorus, and creatinine levels, with normal parathyroid hormone (PTH) levels. This case underscores the critical role of bone scintigraphy in the early diagnosis and monitoring of metastatic bone disease in breast cancer patients. It highlights the superiority of bone scintigraphy over CT scans in detecting early-stage visceral calcification, emphasizing the importance of early recognition and management of metastatic calcification and hypercalcemia in cancer patients.