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<p>High-grade glioma (HGG) arising from a mature ovarian teratoma is extremely rare and its genetic alterations remain largely unknown. We report a case of WHO Grade 4 HGG (HGG-G4) developing 3 years after cystectomy for ovarian mature teratoma, where a WHO Grade 3 HGG (HGG-G3) was identified upon pathological reevaluation. Whole-exome sequencing confirmed the clonal relationship between HGG-G3 and HGG-G4, revealing genome-wide copy-neutral loss of heterozygosity, copy-number alterations, and whole-genome doubling in both HGGs. Genomic and epigenetic analyses have suggested multistep tumorigenesis and clonal alteration during the clinical course, particularly in response to chemotherapy, in HGGs arising from ovarian teratomas.</p>

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High-grade gliomas derived from an ovarian mature teratoma: clonal dynamics and genetic insights

  • 期刊论文

  • 发表日期：

    2025年9月8日

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  • Kota Yamauchi,
  • Junzo Hamanishi,
  • Koichi Watanabe,
  • Nobuyuki Kakiuchi,
  • Yasuhide Takeuchi,
  • Hiroyuki Katsuragawa,
  • Koji Yamanoi,
  • Takashi Motohashi,
  • Yuko Hosoe,
  • Ken Yamaguchi,
  • Kiyoshi Yamaguchi,
  • Seiya Imoto,
  • Tsutomu Tabata,
  • Yoichi Furukawa,
  • Yohei Mineharu,
  • Yoshiki Arakawa,
  • Seishi Ogawa,
  • Sachiko Minamiguchi,
  • Masaki Mandai

摘要

High-grade glioma (HGG) arising from a mature ovarian teratoma is extremely rare and its genetic alterations remain largely unknown. We report a case of WHO Grade 4 HGG (HGG-G4) developing 3 years after cystectomy for ovarian mature teratoma, where a WHO Grade 3 HGG (HGG-G3) was identified upon pathological reevaluation. Whole-exome sequencing confirmed the clonal relationship between HGG-G3 and HGG-G4, revealing genome-wide copy-neutral loss of heterozygosity, copy-number alterations, and whole-genome doubling in both HGGs. Genomic and epigenetic analyses have suggested multistep tumorigenesis and clonal alteration during the clinical course, particularly in response to chemotherapy, in HGGs arising from ovarian teratomas.