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<p>Solid adenocarcinoma with signet-ring cell features (SRCF) is an extremely rare variant of lung adenocarcinoma, often mimicking metastatic tumors from other sites. Accurate diagnosis relies heavily on immunohistochemical profiling. This report discusses a case of solid adenocarcinoma with SRCF presenting with pleural thickening, highlighting diagnostic challenges and treatment limitations. We report a 36-year-old smoker with progressive dyspnea and pleuritic pain. Imaging revealed pleural thickening and pulmonary nodules. Histopathology showed solid adenocarcinoma with SRCF, confirmed by immunohistochemistry as primary pulmonary signet-ring cell carcinoma (SRCC). Despite chemotherapy, the disease progressed, and the patient succumbed within 3 months. Primary pulmonary solid adenocarcinoma with SRCF is associated with high mortality and diagnostic complexity. Immunohistochemical markers remain pivotal in establishing its pulmonary origin. This case reinforced the urgent need for better diagnostic techniques and therapies.</p> Graphical abstract <p></p>

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Diagnostic and clinical challenges of primary pulmonary solid adenocarcinoma with signet-ring cell features: a case report with unusual presentation and literature review

  • 期刊论文

  • 发表日期：

    2025年5月9日

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  • Noura A. A. Ebrahim,
  • Moamen O. Othman,
  • Ahmed M. Fahmy,
  • Neveen S. Tahoun,
  • Rasha A. Salama,
  • Nermeen Mostafa Mahmoud,
  • Habiba Elfandy

摘要

Solid adenocarcinoma with signet-ring cell features (SRCF) is an extremely rare variant of lung adenocarcinoma, often mimicking metastatic tumors from other sites. Accurate diagnosis relies heavily on immunohistochemical profiling. This report discusses a case of solid adenocarcinoma with SRCF presenting with pleural thickening, highlighting diagnostic challenges and treatment limitations. We report a 36-year-old smoker with progressive dyspnea and pleuritic pain. Imaging revealed pleural thickening and pulmonary nodules. Histopathology showed solid adenocarcinoma with SRCF, confirmed by immunohistochemistry as primary pulmonary signet-ring cell carcinoma (SRCC). Despite chemotherapy, the disease progressed, and the patient succumbed within 3 months. Primary pulmonary solid adenocarcinoma with SRCF is associated with high mortality and diagnostic complexity. Immunohistochemical markers remain pivotal in establishing its pulmonary origin. This case reinforced the urgent need for better diagnostic techniques and therapies.

Graphical abstract