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<p>A 69-year-old male presented to our clinic with bloody faecal matter. Examination revealed a 60-mm type 1 tumour on the posterior rectal wall and a 15-mm type Is tumour on the anterior rectal wall. R0 resection was performed via laparoscopic perineal rectal resection (extraperitoneal colectomy). Immunohistochemical staining led to the diagnosis of anorectal malignant peripheral nerve sheath tumour on the posterior rectal wall and anorectal malignant melanoma on the anterior rectal wall. Peritoneal dissemination occurred 10&#xa0;months after resection, with the appearance of liver tumours. The liver was biopsied and pathological examination revealed metastasis due to malignant peripheral nerve sheath tumours. Primary treatment with doxorubicin plus ifosfamide and secondary treatment with etoposide plus carboplatin were ineffective.</p>

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Simultaneous malignant peripheral nerve sheath tumour and malignant melanoma of the anorectal region

  • 期刊论文

  • 发表日期：

    2025年4月4日

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  • Nobuto Yamazaki,
  • Yoshinori Kikuchi,
  • Kimihiko Yoshida,
  • Yasuyuki Miura,
  • Takamaru Koda,
  • Yasuo Nagashima,
  • Takayuki Suzuki,
  • Satoru Kagami,
  • Tomoaki Kaneko,
  • Hiroyuki Shiokawa,
  • Nanako Inoue,
  • Naoki Onda,
  • Mitsunori Ushigome,
  • Akiharu Kurihara,
  • Yasuko Kurose,
  • Naobumi Tochigi,
  • Kimihiko Funahashi

摘要

A 69-year-old male presented to our clinic with bloody faecal matter. Examination revealed a 60-mm type 1 tumour on the posterior rectal wall and a 15-mm type Is tumour on the anterior rectal wall. R0 resection was performed via laparoscopic perineal rectal resection (extraperitoneal colectomy). Immunohistochemical staining led to the diagnosis of anorectal malignant peripheral nerve sheath tumour on the posterior rectal wall and anorectal malignant melanoma on the anterior rectal wall. Peritoneal dissemination occurred 10 months after resection, with the appearance of liver tumours. The liver was biopsied and pathological examination revealed metastasis due to malignant peripheral nerve sheath tumours. Primary treatment with doxorubicin plus ifosfamide and secondary treatment with etoposide plus carboplatin were ineffective.