Purpose of Review <p>Dermatological lesions in the intensive care unit (ICU) pose significant challenges due to their potential to indicate life-threatening conditions or contribute to patient morbidity if left unaddressed. This review aims to provide an overview of the exogenous skin injuries commonly encountered in critical care settings, with a focus on their identification, prevention, and management.</p> Recent Findings <p>In recent years, there has been an increased awareness of medical device-related pressure injuries (MDRPI) and other exogenous skin insults in ICU patients, such as pulse oximeter lesions, oxygen device-related injuries, endotracheal tube-related injuries, urinary catheter-associated skin injuries, prone positioning-related dermatological complications, and medical adhesive-related skin injury (MARSI). These conditions are preventable through regular skin assessments, proper device repositioning, and the use of protective interventions. Multidisciplinary care involving dermatologists, wound care specialists, intensivists, and critical care nurses has been shown to improve outcomes.</p> Summary <p>This review highlights the importance of early recognition, accurate diagnosis, and targeted prevention of exogenous skin lesions in the ICU. With a focus on proactive strategies and interdisciplinary collaboration, healthcare providers can significantly enhance patient care and outcomes in the ICU.</p>