Purpose of Review <p>This review examined the relationship between social determinants of health (SDOH) and delirium in adults, identifying which social factors have been studied and how they influence delirium development during hospitalization.</p> Recent Findings <p>Eight high-quality studies revealed that socioeconomic disadvantage consistently increases delirium risk, with low household income, informal employment and residence in disadvantaged neighborhoods all showing significant association. Educational attainment showed mixed results across studies, with some evidence suggesting a protective effect of higher education. Regular physical exercise demonstrates protective benefits, while limited insurance coverage appears to elevate delirium risk substantially.</p> Summary <p>SDOH significantly influences delirium risk, with socioeconomic factors showing strongest associations. Future research opportunities include addressing sample limitations through more diverse populations and exploring mechanisms linking socioeconomic disadvantages to delirium. Clinical practice could benefit from integrating SDOH screening into delirium risk assessment.</p>