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Purpose of Review <p>This review provides an overview of the relationship among nutritional, environmental, and genetic factors in the development of the chronic inflammatory state, starting from the inflammatory bowel disease (IBD) up to the onset of Colorectal Cancer (CRC). Finally, it also examines potential prospects and future topics of research taking into account the relation between nutrition and epigenetic factors.</p> Recent Findings <p>Evidence indicates&#xa0;that genetic and lifestyle-related factors play a crucial role in CRC etiology. Dietary intake may induce epigenetic alterations which in turn, result in carcinogenesis. Several bioactive components can modify epigenetic mechanisms, required for gene activation or silencing, thus, representing a potential way of preventing CRC.</p> Summary <p>The gene-diet interaction analysis suggested some functions and pathways that may affect the CRC development. In this view, personalized nutrition, which is an approach that combines with new omics technologies, could represent a new possible key for personalized prevention and treatment in association with other cancer prevention and chemotherapeutic therapies.</p>

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Nutrition, Environment, and Genetics in Colorectal Cancer. Epigenetics and Possible Future Perspective

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年10月18日

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  • Stefano Brandolino,
  • Marica Franzago,
  • Giovanna Murmura,
  • Fabrizio Ricci,
  • Valentina Gatta,
  • Liborio Stuppia,
  • Ester Vitacolonna

摘要

Purpose of Review

This review provides an overview of the relationship among nutritional, environmental, and genetic factors in the development of the chronic inflammatory state, starting from the inflammatory bowel disease (IBD) up to the onset of Colorectal Cancer (CRC). Finally, it also examines potential prospects and future topics of research taking into account the relation between nutrition and epigenetic factors.

Recent Findings

Evidence indicates that genetic and lifestyle-related factors play a crucial role in CRC etiology. Dietary intake may induce epigenetic alterations which in turn, result in carcinogenesis. Several bioactive components can modify epigenetic mechanisms, required for gene activation or silencing, thus, representing a potential way of preventing CRC.

Summary

The gene-diet interaction analysis suggested some functions and pathways that may affect the CRC development. In this view, personalized nutrition, which is an approach that combines with new omics technologies, could represent a new possible key for personalized prevention and treatment in association with other cancer prevention and chemotherapeutic therapies.