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Purpose of the Review <p>Sesame seed meal (SSM), the by-product from sesame oil production, contains high amounts of bioactive compounds such as lignans, dietary fiber, and proteins. Increasing demand for functional foods and nutraceuticals for health enhancement has inspired an upturn in research exploring novel sources of natural, safe, and effective bioactive components. This is an up-to-date and comprehensive review of SSM, focusing on the role of its proteins/peptides in modulating physiological processes in the light of potential health improvement.</p> Recent Findings <p>Mounting evidence from in vitro, in vivo and some clinical studies, suggest that SSM proteins and bioactive peptides interacted with, and effectively modulated vital molecular targets, metabolism, and physiological processes central to the pathogenesis of some chronic ailments. These include nuclear factor erythroid 2-related factor 2 pathway activation, regulation of renin-angiotensin-aldosterone system and metabolic enzymes, inhibition of aberrant protein aggregation, boosting antioxidant status, countering oxidative stress, modulating blood lipid levels, etc., resulting in anti-diabetic, anti-obesity, anti-hyperlipidemia, and neuroprotective effects.</p> Summary <p>Consumption of SSM and its bioactive proteins/peptides can enhance the physiological processes vital for health and well-being, and perhaps counter the molecular perturbations underlying the development of chronic diseases. SSM proteins and biopeptides are highly promising bioactive ingredients that can be use in the development of functional foods and nutraceuticals aimed at health improvement in humans.</p>

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Bio-Functionalities of Sesame (Sesamum indicum L.) Seed Meal and Proteins: Illuminating Their Novel Role and Mechanisms as Versatile Functional Food Ingredients for Health Promotion

  • 期刊论文

  • 发表日期：

    2025年8月18日

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  • Fredrick Nwude Eze,
  • Rattana Muangrat,
  • Wachira Jirarattanarangsri,
  • Thanyaporn Siriwoharn,
  • Yongyut Chalermchat

摘要

Purpose of the Review

Sesame seed meal (SSM), the by-product from sesame oil production, contains high amounts of bioactive compounds such as lignans, dietary fiber, and proteins. Increasing demand for functional foods and nutraceuticals for health enhancement has inspired an upturn in research exploring novel sources of natural, safe, and effective bioactive components. This is an up-to-date and comprehensive review of SSM, focusing on the role of its proteins/peptides in modulating physiological processes in the light of potential health improvement.

Recent Findings

Mounting evidence from in vitro, in vivo and some clinical studies, suggest that SSM proteins and bioactive peptides interacted with, and effectively modulated vital molecular targets, metabolism, and physiological processes central to the pathogenesis of some chronic ailments. These include nuclear factor erythroid 2-related factor 2 pathway activation, regulation of renin-angiotensin-aldosterone system and metabolic enzymes, inhibition of aberrant protein aggregation, boosting antioxidant status, countering oxidative stress, modulating blood lipid levels, etc., resulting in anti-diabetic, anti-obesity, anti-hyperlipidemia, and neuroprotective effects.

Summary

Consumption of SSM and its bioactive proteins/peptides can enhance the physiological processes vital for health and well-being, and perhaps counter the molecular perturbations underlying the development of chronic diseases. SSM proteins and biopeptides are highly promising bioactive ingredients that can be use in the development of functional foods and nutraceuticals aimed at health improvement in humans.