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<p>Strophioglandins A−C (<b>1</b>−<b>3</b>), three highly rearranged norditerpenoids featuring an unusual tricyclo[6.4.1.0<sup>4,13</sup>]tridecane core, were isolated from <i>Strophioblachia glandulosa</i> var. <i>cordifolia</i>. Integrated spectroscopic analyses, X-ray crystallography, and ECD calculations synergistically determined their molecular architectures. Remarkably, all compounds manifested potent anti-inflammatory effects in LPS-activated RAW264.7 cells with IC<sub>50</sub> values ranging from 7.83 ± 1.11 to 15.09 ± 1.21&#xa0;μM. Mechanism study revealed that strophioglandin A (<b>1</b>), the most potent compound, could suppress the expression of multiple inflammatory factors by inhibiting the P38 and Erk1/2 MAPK signaling pathways.</p> Graphical Abstract <p></p>

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Strophioglandins A–C, highly rearranged norditerpenoids with an unusual tricyclo[6.4.1.04,13]tridecane core from Strophioblachia glandulosa var. cordifolia

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年9月15日

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  • Jian-Kai Xia,
  • Lei-Ming Wu,
  • Wei-Ye Wu,
  • Dong Huang,
  • Fang-Yu Yuan,
  • Lei Li,
  • Shu-Qi Wu,
  • Yan-Jiang Zhang,
  • Tao Yuan,
  • Xin Chen,
  • Gui-Hua Tang,
  • Jia-Luo Huang,
  • Sheng Yin

摘要

Strophioglandins A−C (1−3), three highly rearranged norditerpenoids featuring an unusual tricyclo[6.4.1.04,13]tridecane core, were isolated from Strophioblachia glandulosa var. cordifolia. Integrated spectroscopic analyses, X-ray crystallography, and ECD calculations synergistically determined their molecular architectures. Remarkably, all compounds manifested potent anti-inflammatory effects in LPS-activated RAW264.7 cells with IC50 values ranging from 7.83 ± 1.11 to 15.09 ± 1.21 μM. Mechanism study revealed that strophioglandin A (1), the most potent compound, could suppress the expression of multiple inflammatory factors by inhibiting the P38 and Erk1/2 MAPK signaling pathways.

Graphical Abstract